miRNA，肠道原生动物和弓形虫世界的新视角。
miRNA, New Perspective to World of Intestinal Protozoa and Toxoplasma.
机构信息
Department of Laboratory Sciences and Microbiology, Faculty of Medical Sciences, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Acta Parasitol. 2024 Sep;69(3):1690-1703. doi: 10.1007/s11686-024-00888-x. Epub 2024 Aug 19.
BACKGROUND
miRNAs are known as non-coding RNAs that can regulate gene expression. They are reported in many microorganisms and their host cells. Parasite infection can change or shift host miRNAs expression, which can aim at both parasite eradication and infection.
PURPOSE
This study dealt with examination of miRNA expressed in intestinal protozoan, coccidia , as well as profile changes in host cell miRNA after parasitic infection and their role in protozoan clearance/ survival.
METHODS
The authors searched ISI Web of Sciences, Pubmed, Scholar, Scopus, another databases and articles published up to 2024 were included. The keywords of miRNA, intestinal protozoa, toxoplasma and some words associated with topics were used in this search.
RESULTS
Transfection of miRNA mimics or inhibitors can control parasitic diseases, and be introduced as a new therapeutic option in parasitology.
CONCLUSION
This review can be used to provide up-to date knowledge for future research on these issues.
背景
miRNA 被称为非编码 RNA，能够调控基因表达。它们在许多微生物及其宿主细胞中均有报道。寄生虫感染可以改变或改变宿主 miRNA 的表达，这既可以针对寄生虫的清除，也可以针对寄生虫的感染。
目的
本研究旨在检测肠道原生动物、球虫中的 miRNA 表达情况，以及寄生虫感染后宿主细胞 miRNA 的谱变化及其在原生动物清除/存活中的作用。
方法
作者检索了 ISI Web of Sciences、Pubmed、Scholar、Scopus 等数据库，纳入截至 2024 年发表的文章。本研究的检索词包括 miRNA、肠道原生动物、弓形虫和一些与主题相关的词。
结果
转染 miRNA 模拟物或抑制剂可以控制寄生虫病，并作为寄生虫学中的一种新的治疗选择。
结论
本综述可用于为今后对这些问题的研究提供最新知识。
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