• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

绵毛尼泊尔菊三七多糖组分及其通过减轻氧化应激对链脲佐菌素诱导的糖尿病小鼠的肾脏保护作用。

Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress.

作者信息

Guo Hai-Hui, Wu Lei, Mi Dan, Zhang Xing-Yu, He Fu-Mei, Lei Ting, Wang Fu-Sheng

机构信息

College of Pharmacy, Dali University, Xueren Road 2, Xiaguan, Dali, 671000, Yunnan Province, People's Republic of China.

Yunnan Key Laboratory of Screening and Research On Anti-Pathogenic Plant Resources From Western Yunnan, Dali, 671000, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2024 Aug 19;14(1):47. doi: 10.1007/s13659-024-00467-7.

DOI:10.1007/s13659-024-00467-7
PMID:39158797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11333391/
Abstract

Triplostegia glandulifera Wall (T. glandulifera) is an ethnomedicine commonly used by ethnic minorities in Yunnan, China, to treat kidney disease. However, there are few reports on the renoprotective effects of this substance, and the active ingredients remain unclear. In this study, we extracted the polysaccharide fractions TGB and TGC using the water extraction-alcohol precipitation method and determined their molecular weight (Mw) and monosaccharide composition. The study investigated the protective effects of TGB and TGC fractions against diabetic nephropathy (DN) using an in vitro high glucose-induced HRMCs model and an in vivo STZ-induced diabetic mouse model. HPLC analysis revealed that TGB contained D-galacturonic acid, D-glucose, D-galactose, and D-arabinose, and had a lower Mw than TGC. In vitro, TGB showed concentration-dependent antioxidant activity and effectively reduced abnormal proliferation and while attenuating oxidative stress in HRMCs. In mice with diabetes, TGB corrected the dysregulation of glucose-lipid metabolism and alleviated oxidative stress in the kidneys. Additionally, it improved renal function and reduced renal tissue damage. The study suggests that the low Mw polysaccharides (TGB) have better activity against DN through the antioxidative stress mechanism.

摘要

珠子参是中国云南少数民族常用的一种民族药，用于治疗肾脏疾病。然而，关于这种物质的肾脏保护作用的报道很少，其活性成分也尚不清楚。在本研究中，我们采用水提醇沉法提取了多糖组分TGB和TGC，并测定了它们的分子量（Mw）和单糖组成。本研究使用体外高糖诱导的HRMCs模型和体内链脲佐菌素诱导的糖尿病小鼠模型，研究了TGB和TGC组分对糖尿病肾病（DN）的保护作用。高效液相色谱分析显示，TGB含有D-半乳糖醛酸、D-葡萄糖、D-半乳糖和D-阿拉伯糖，且Mw低于TGC。在体外，TGB表现出浓度依赖性抗氧化活性，并有效降低了HRMCs中的异常增殖，同时减轻了氧化应激。在糖尿病小鼠中，TGB纠正了糖脂代谢紊乱，减轻了肾脏的氧化应激。此外，它还改善了肾功能，减少了肾组织损伤。该研究表明，低Mw多糖（TGB）通过抗氧化应激机制对DN具有更好的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/644a83bac042/13659_2024_467_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/4e896702a3a5/13659_2024_467_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/9c19db00bf62/13659_2024_467_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/f9ae691cad08/13659_2024_467_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/e4324b269e68/13659_2024_467_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/659842b53c33/13659_2024_467_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/9b442b0ce7fc/13659_2024_467_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/057eb4aa5f9d/13659_2024_467_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/90ec1a7a6cce/13659_2024_467_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/efadd9f61a27/13659_2024_467_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/644a83bac042/13659_2024_467_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/4e896702a3a5/13659_2024_467_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/9c19db00bf62/13659_2024_467_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/f9ae691cad08/13659_2024_467_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/e4324b269e68/13659_2024_467_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/659842b53c33/13659_2024_467_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/9b442b0ce7fc/13659_2024_467_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/057eb4aa5f9d/13659_2024_467_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/90ec1a7a6cce/13659_2024_467_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/efadd9f61a27/13659_2024_467_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24db/11333391/644a83bac042/13659_2024_467_Fig10_HTML.jpg

相似文献

1
Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress.绵毛尼泊尔菊三七多糖组分及其通过减轻氧化应激对链脲佐菌素诱导的糖尿病小鼠的肾脏保护作用。
Nat Prod Bioprospect. 2024 Aug 19;14(1):47. doi: 10.1007/s13659-024-00467-7.
2
Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.辣木籽提取物通过增加 GSK-3β 活性和激活 Nrf2/HO-1 通路来保护糖尿病肾病大鼠的肾脏功能。
Phytomedicine. 2022 Jan;95:153856. doi: 10.1016/j.phymed.2021.153856. Epub 2021 Nov 16.
3
Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells.纤细琉璃苣改善高脂饮食/链脲佐菌素诱导的糖尿病肾病肾损伤并抑制氧化应激诱导的系膜细胞凋亡。
J Ethnopharmacol. 2020 Jun 12;255:112771. doi: 10.1016/j.jep.2020.112771. Epub 2020 Mar 19.
4
Integrated network pharmacology and pharmacological investigations to discover the active compounds of Toona sinensis pericarps against diabetic nephropathy.综合网络药理学和药理学研究以发现香椿果皮抗糖尿病肾病的活性成分。
J Ethnopharmacol. 2024 Oct 28;333:118441. doi: 10.1016/j.jep.2024.118441. Epub 2024 Jun 6.
5
Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway.穿心莲内酯通过Akt/NF-κB途径减轻高血糖介导的肾脏氧化应激和炎症，从而改善糖尿病肾病。
Mol Cell Endocrinol. 2016 Dec 5;437:268-279. doi: 10.1016/j.mce.2016.06.029. Epub 2016 Jul 1.
6
Buyang Huanwu Decoction protects against STZ-induced diabetic nephropathy by inhibiting TGF-β/Smad3 signaling-mediated renal fibrosis and inflammation.补阳还五汤通过抑制TGF-β/Smad3信号介导的肾纤维化和炎症来预防链脲佐菌素诱导的糖尿病肾病。
Chin Med. 2021 Nov 14;16(1):118. doi: 10.1186/s13020-021-00531-1.
7
Anti-diabetic and renoprotective effects of aliskiren in streptozotocin-induced diabetic nephropathy in female rats.阿利吉仑对链脲佐菌素诱导的雌性大鼠糖尿病肾病的抗糖尿病和肾脏保护作用。
Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1315-1324. doi: 10.1007/s00210-016-1299-2. Epub 2016 Sep 9.
8
Astragalus Polysaccharide Ameliorates Renal Inflammatory Responses in a Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.黄芪多糖通过抑制 TLR4/NF-κB 通路改善糖尿病肾病的肾脏炎症反应。
Drug Des Devel Ther. 2023 Jul 19;17:2107-2118. doi: 10.2147/DDDT.S411211. eCollection 2023.
9
Nephroprotective potential of syringic acid in experimental diabetic nephropathy: Focus on oxidative stress and autophagy.原甲酸在实验性糖尿病肾病中的肾保护作用：关注氧化应激和自噬。
Indian J Pharmacol. 2023 Jan-Feb;55(1):34-42. doi: 10.4103/ijp.ijp_671_22.
10
Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice.低分子量桦褐孔菌多糖（LIOP）对高脂饮食/链脲佐菌素诱导的小鼠肾病的肾脏保护作用
Int J Mol Sci. 2016 Sep 13;17(9):1535. doi: 10.3390/ijms17091535.

本文引用的文献

1
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.白藜芦醇通过减轻脂毒性并调节连接黏附分子样/沉默调节蛋白 1 脂质代谢途径的成分表达来改善糖尿病肾病损伤。
Eur J Pharmacol. 2022 Mar 5;918:174776. doi: 10.1016/j.ejphar.2022.174776. Epub 2022 Jan 25.
2
Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.辣木籽提取物通过增加 GSK-3β 活性和激活 Nrf2/HO-1 通路来保护糖尿病肾病大鼠的肾脏功能。
Phytomedicine. 2022 Jan;95:153856. doi: 10.1016/j.phymed.2021.153856. Epub 2021 Nov 16.
3
Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors.
血脂异常、糖尿病与动脉粥样硬化：炎症及活性氧-氧化还原敏感因子的作用
Biomedicines. 2021 Nov 3;9(11):1602. doi: 10.3390/biomedicines9111602.
4
Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.全球、区域和国家慢性肾脏病负担，1990-2017 年：2017 年全球疾病负担研究的系统分析。
Lancet. 2020 Feb 29;395(10225):709-733. doi: 10.1016/S0140-6736(20)30045-3. Epub 2020 Feb 13.
5
Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy.硫化氢：治疗糖尿病肾病的最新进展和展望。
Molecules. 2019 Aug 6;24(15):2857. doi: 10.3390/molecules24152857.
6
Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. seeds.芡实中葡聚糖的结构表征及体外降血糖活性研究。
Carbohydr Polym. 2019 Apr 1;209:363-371. doi: 10.1016/j.carbpol.2019.01.044. Epub 2019 Jan 14.
7
Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences.微血管功能障碍与高血糖：广泛后果的恶性循环。
Diabetes. 2018 Sep;67(9):1729-1741. doi: 10.2337/dbi17-0044.
8
Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy.糖尿病肾病中的氧化应激、细胞凋亡与线粒体功能
Int J Endocrinol. 2018 Apr 1;2018:1875870. doi: 10.1155/2018/1875870. eCollection 2018.
9
Update on Diabetic Nephropathy: Core Curriculum 2018.糖尿病肾病更新：2018 年核心课程。
Am J Kidney Dis. 2018 Jun;71(6):884-895. doi: 10.1053/j.ajkd.2017.10.026. Epub 2018 Feb 3.
10
Anti-diabetic polysaccharides from natural sources: A review.天然来源的抗糖尿病多糖：综述。
Carbohydr Polym. 2016 Sep 5;148:86-97. doi: 10.1016/j.carbpol.2016.02.060. Epub 2016 Apr 13.