McGill Jodi L, Loving Crystal L, Kehrli Marcus E
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa, USA.
Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, Iowa, USA.
Annu Rev Anim Biosci. 2025 Feb;13(1):255-275. doi: 10.1146/annurev-animal-111523-102209. Epub 2024 Aug 19.
Immune modulation in animal agriculture has been of research interest for several decades, yet only a few immunomodulators have received regulatory approval in the United States and around the world. In this review, we summarize market and regulatory environments impacting commercial development of immunomodulators for use in livestock and poultry. In the United States, very few immunomodulators have received regulatory approval for use in livestock by either the US Department of Agriculture Center for Veterinary Biologics or the Food and Drug Administration (FDA). To date, only one immunomodulator has received FDA approval, and an extensive body of peer-reviewed literature is available regarding the basis for its use and health benefits. We present a more thorough review of the history and impact of this immune restorative. Finally, we discuss the interaction of immunomodulators on health, metabolism, and other factors impacting the future of immune modulation in livestock.
几十年来，动物农业中的免疫调节一直是研究热点，但在美国和全球范围内，只有少数免疫调节剂获得了监管批准。在本综述中，我们总结了影响用于家畜和家禽的免疫调节剂商业开发的市场和监管环境。在美国，美国农业部兽医生物制品中心或食品药品监督管理局（FDA）批准用于家畜的免疫调节剂极少。迄今为止，只有一种免疫调节剂获得了FDA批准，并且有大量经过同行评审的文献可用于说明其使用依据和健康益处。我们对这种免疫恢复剂的历史和影响进行了更全面的综述。最后，我们讨论了免疫调节剂对健康、新陈代谢以及其他影响家畜免疫调节未来的因素的相互作用。
