Department of acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
PLoS One. 2024 Aug 19;19(8):e0308151. doi: 10.1371/journal.pone.0308151. eCollection 2024.
Diverse studies have revealed discrepant evidence concerning the causal association between Corona Virus Disease 2019 (COVID-19) and COVID-19 vaccination in relation to migraines. Investigating the correlation between the former two factors and migraines can facilitate policymakers in the precise formulation of comprehensive post-pandemic interventions while urging the populace to adopt a judicious perspective on COVID-19 vaccination.
We undertook a Mendelian randomization (MR) study. The primary assessment of the causal relationship between the three different COVID-19 exposures and migraine was conducted using the standard inverse variance weighted (IVW) approach. In the supplementary analysis, we also employed two methodologies: the weighted median estimator (WME) and the MR-Egger regression. Ultimately, the reliability and stability of the outcomes were assessed via Cochran's Q test, the leave-one-out method, the MR-Egger intercept test, and the MR pleiotropy residual sum and outlier (MR-PRESSO) test.
The results indicate an absence of correlation between genetically predicted COVID-19 (①Very severe respiratory confirmed COVID-19: odds ratio [OR], 1.0000881; 95%CI, 0.999748-1.000428; p = 0.6118; ②Hospitalized COVID-19: OR, 1.000024; 95%CI, 0.9994893-1.000559; p = 0.931;③SARS-CoV-2 infection: OR, 1.000358; 95%CI, 0.999023-1.001695; p = 0.5993) and the risk of migraine. Furthermore, the MR-Egger regression and WME also yielded no evidence of COVID-19 elevating the risk of migraine occurrence. Sensitivity analysis affirmed the robustness and consistency of all outcomes.
The results of this study do not offer genetic evidence to substantiate a causal relationship between COVID-19 and migraines. Thus, the deduction drawn from COVID-19 genetic data is that COVID-19 vaccination is unlikely to exert an impact on the occurrence of migraines, though this conclusion warrants further investigation.
多项研究表明，新冠病毒疾病 2019（COVID-19）与 COVID-19 疫苗接种与偏头痛之间的因果关联存在不一致的证据。研究这两个前因与偏头痛之间的相关性，可以帮助政策制定者在制定全面的大流行后干预措施时更加准确，并促使民众对 COVID-19 疫苗接种采取明智的态度。
我们进行了孟德尔随机化（MR）研究。使用标准逆方差加权（IVW）方法对三种不同的 COVID-19 暴露与偏头痛之间的因果关系进行了主要评估。在补充分析中，我们还采用了两种方法：加权中位数估计器（WME）和 MR-Egger 回归。最终，通过 Cochrane Q 检验、留一法、MR-Egger 截距检验和 MR 偏倚残差总和和异常值（MR-PRESSO）检验来评估结果的可靠性和稳定性。
结果表明，遗传预测的 COVID-19（①严重呼吸道确诊 COVID-19：比值比 [OR]，1.0000881；95%置信区间，0.999748-1.000428；p=0.6118；②住院 COVID-19：OR，1.000024；95%置信区间，0.9994893-1.000559；p=0.931；③SARS-CoV-2 感染：OR，1.000358；95%置信区间，0.999023-1.001695；p=0.5993）与偏头痛风险之间不存在相关性。此外，MR-Egger 回归和 WME 也没有发现 COVID-19 会增加偏头痛发生的风险。敏感性分析证实了所有结果的稳健性和一致性。
本研究结果没有提供遗传证据支持 COVID-19 与偏头痛之间存在因果关系。因此，从 COVID-19 遗传数据中得出的结论是，COVID-19 疫苗接种不太可能对偏头痛的发生产生影响，但这一结论需要进一步研究。
