Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502284, Telangana, India.
Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502284, Telangana, India.
ACS Appl Bio Mater. 2024 Sep 16;7(9):5885-5905. doi: 10.1021/acsabm.4c00879. Epub 2024 Aug 19.
Cartilage tissue engineering remains a formidable challenge due to its complex, avascular structure and limited regenerative capacity. Traditional approaches, such as microfracture, autografts, and stem cell delivery, often fail to restore functional tissue adequately. Recently, there has been a surge in the exploration of new materials that mimic the extracellular microenvironment necessary to guide tissue regeneration. This review investigates the potential of peptide-based hydrogels as an innovative solution for cartilage regeneration. These hydrogels, formed via supramolecular self-assembly, exhibit excellent properties, including biocompatibility, ECM mimicry, and controlled biodegradation, making them highly suitable for cartilage tissue engineering. This review explains the structure of cartilage and the principles of supramolecular and peptide hydrogels. It also delves into their specific properties relevant to cartilage regeneration. Additionally, this review presents recent examples and a comparative analysis of various peptide-based hydrogels used for cartilage regeneration. The review also addresses the translational challenges of these materials, highlighting regulatory hurdles and the complexities of clinical application. This comprehensive investigation provides valuable insights for biomedical researchers, tissue engineers, and clinical professionals aiming to enhance cartilage repair methodologies.
由于软骨组织具有复杂的、无血管的结构和有限的再生能力，其组织工程仍然是一个巨大的挑战。传统的方法，如微骨折、自体移植物和干细胞递送，往往不能充分恢复功能组织。最近，人们对模仿引导组织再生所需的细胞外微环境的新材料的探索激增。本综述研究了基于肽的水凝胶作为软骨再生的创新解决方案的潜力。这些水凝胶通过超分子自组装形成，具有优异的性能，包括生物相容性、细胞外基质模拟和可控的生物降解性，非常适合软骨组织工程。本综述解释了软骨的结构以及超分子和肽水凝胶的原理。它还深入探讨了它们与软骨再生相关的特定性质。此外，本综述还介绍了最近用于软骨再生的各种基于肽的水凝胶的实例和比较分析。该综述还讨论了这些材料的转化挑战，强调了监管障碍和临床应用的复杂性。这项全面的研究为旨在增强软骨修复方法的生物医学研究人员、组织工程师和临床专业人员提供了有价值的见解。
