Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
J Biomater Sci Polym Ed. 2023 Apr;34(5):695-714. doi: 10.1080/09205063.2022.2088530. Epub 2023 Feb 6.
Due to a lack of sufficient blood supply and unique physicochemical properties, the treatment of injured cartilage is laborious and needs an efficient strategy. Unfortunately, most of the current therapeutic approaches are, but not completely, unable to restore the function of injured cartilage. Tissue engineering-based modalities are an alternative option to reconstruct the injured tissue. Considering the unique structure and consistency of cartilage tissue (osteochondral junction), it is mandatory to apply distinct biomaterials with unique properties slightly different from scaffolds used for soft tissues. PCL is extensively used for the fabrication of fine therapeutic scaffolds to accelerate the restorative process. Thermosensitive PCL hydrogels with distinct chemical compositions have paved the way for sophisticated cartilage regeneration. This review aimed to collect recent findings regarding the application of PCL in hydrogels blended with natural, synthetic materials in the context of cartilage healing.
由于血液供应不足和独特的物理化学性质，受伤软骨的治疗很困难，需要一种有效的策略。不幸的是，目前大多数的治疗方法都不能完全恢复受伤软骨的功能。基于组织工程的方法是重建受伤组织的另一种选择。考虑到软骨组织（骨软骨结合部）的独特结构和一致性，必须使用具有独特性能的不同生物材料，这些性能与用于软组织的支架略有不同。PCL 被广泛用于制造精细的治疗性支架，以加速修复过程。具有不同化学成分的温敏 PCL 水凝胶为复杂的软骨再生铺平了道路。本综述旨在收集关于 PCL 在水凝胶中与天然、合成材料混合应用的最新发现，这些水凝胶在软骨愈合方面具有潜在的应用价值。
