“HALP 评分与急性缺血性脑卒中患者感染的相关性”。

"The association between HALP score and infection in acute ischemic stroke patients".

机构信息

Department of Neurology, Health Sciences University of Turkey, Diyarbakır Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.

Department of Dietetics and Nutrition, Dicle University, Ataturk Faculty of Health Sciences, Diyarbakir, Turkey.

出版信息

J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107929. doi: 10.1016/j.jstrokecerebrovasdis.2024.107929. Epub 2024 Aug 17.

DOI:10.1016/j.jstrokecerebrovasdis.2024.107929

PMID:39159902

Abstract

BACKGROUND AND PURPOSE

Stroke-associated infection (SAI) is related to increased mortality in acute ischemic stroke (AIS) cases. The HALP index is used to evaluate nutrition and inflammation. Our research aimed to assess the relation between HALP scores and infection risk in AIS cases.

MATERIALS AND METHODS

132 cases of acute ischemic stroke were registered. 77 cases were male and 55 cases were female. The median age of the attending cases was 66 (35-104) years. Laboratory variables were assessed within 24 h after hospitalization in the neurology care unit. The HALP score is evaluated utilizing the formula "Hemoglobin (g/dL) × Albumin (g/dL) × Lymphocyte (/10^3/uL) / Platelet (/10^3/uL)".

RESULTS

Cases were separated into two groups according to their corresponding HALP score. Group-1 cases have a low HALP score (HALP score ≤ 18227,93). Group-2 cases have a high HALP score (HALP score > 18227,93). 26 (19.6 %) cases were diagnosed with various infections after hospitalization in the neurology care unit. Urinary tract infections were frequent infection causes in AIS cases (13 cases, 50 %). Pneumonia was observed in 8 cases, making up 30 % of the total cases. Another infection was seen in 5 (20 %) of the cases. The frequently encountered bacteria were Escherichia coli ESBL + (n = 7, 27 %) and Staphylococcus aureus (n = 6, 23 %). The mortality ratio was higher in Group-1 cases than in Group-2 cases (34 % vs 7 %).

CONCLUSIONS

This investigation has suggested a relationship between infection and HALP score in AIS patients.

摘要

背景与目的

卒中相关性感染（SAI）与急性缺血性卒中（AIS）患者的死亡率增加有关。HALP 指数用于评估营养和炎症情况。我们的研究旨在评估 HALP 评分与 AIS 患者感染风险之间的关系。

材料与方法

共登记了 132 例急性缺血性卒中患者。77 例为男性，55 例为女性。就诊患者的中位年龄为 66（35-104）岁。实验室变量在神经病学护理单元住院后 24 小时内进行评估。HALP 评分通过公式“血红蛋白（g/dL）×白蛋白（g/dL）×淋巴细胞（/10^3/μL）/血小板（/10^3/μL）”进行评估。

结果

根据相应的 HALP 评分，将患者分为两组。组 1 患者的 HALP 评分较低（HALP 评分≤18227.93），组 2 患者的 HALP 评分较高（HALP 评分＞18227.93）。26 例（19.6%）患者在神经病学护理单元住院后被诊断出患有各种感染。尿路感染是 AIS 患者常见的感染原因（13 例，占 50%）。8 例患者患有肺炎，占总数的 30%。另外 5 例患者（20%）存在其他感染。常见细菌为产 ESBL 大肠杆菌（n=7，27%）和金黄色葡萄球菌（n=6，23%）。组 1 患者的死亡率高于组 2 患者（34% vs 7%）。