发皮质醇浓度与非西班牙裔白种人青少年后期的肥胖程度呈正相关。

Hair cortisol concentrations are associated with greater adiposity in late adolescence amongst non-Hispanic White individuals.

机构信息

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Department of Population Medicine, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Pediatr Obes. 2024 Dec;19(12):e13164. doi: 10.1111/ijpo.13164. Epub 2024 Aug 19.

DOI:10.1111/ijpo.13164

PMID:39160072

Abstract

INTRODUCTION

Hair cortisol concentration (HCC) is a biomarker of long-term stress. Higher HCC is associated with higher adiposity in adults; however, associations are not well characterized in adolescents.

OBJECTIVE

To examine cross-sectional associations of HCC with adiposity in late adolescence.

METHODS

Amongst 336 non-Hispanic White participants (48.5% female, mean 17.7 years) in Project Viva, we used multivariable linear regression models, overall and sex-stratified, to estimate associations of HCC with body mass index (BMI), bioelectric impedance (BIA) percent body fat, waist circumference (WC) and dual X-ray absorptiometry-measured percent and total fat or trunk fat mass. We adjusted models for age and known predictors of adiposity.

RESULTS

Median (interquartile range) HCC was 2.1 pm/mg (1.0-4.5) and mean (SD) BMI was 23.1 kg/m (3.9), BIA %body fat 20.2% (9.9) and WC 80.6 cm (10.9). In adjusted models, higher HCC (per doubling) was associated with higher BMI (β = 0.19 kg/m; 95%CI 0.00, 0.37) and BIA percent body fat (β = 0.41%; 95%CI 0.04, 0.77). We observed no evidence of effect modification by sex.

CONCLUSIONS

Higher HCC was associated with greater adiposity in late adolescence. Further research is needed to disentangle the relationship between HCC and adolescent adiposity, including the temporal direction of the relationship and sex-specific associations.

摘要

简介

头发皮质醇浓度（HCC）是长期压力的生物标志物。成年人中，较高的 HCC 与较高的肥胖有关；然而，在青少年中，这些关联尚未得到很好的描述。

目的

研究 HCC 与青春期后期肥胖的横断面关联。

方法

在 Viva 项目中，我们对 336 名非西班牙裔白人参与者（48.5%为女性，平均年龄 17.7 岁）进行了研究，我们使用多变量线性回归模型，整体和性别分层，来估计 HCC 与体重指数（BMI）、生物电阻抗（BIA）体脂肪百分比、腰围（WC）和双能 X 射线吸收法测量的体脂肪百分比和总量或躯干脂肪量的关联。我们调整了模型以控制年龄和已知的肥胖预测因素。

结果

中位数（四分位距）HCC 为 2.1 pm/mg（1.0-4.5），平均（SD）BMI 为 23.1 kg/m（3.9），BIA 体脂肪百分比为 20.2%（9.9）和 WC 为 80.6 cm（10.9）。在调整后的模型中，HCC 每增加一倍（per doubling）与 BMI（β=0.19 kg/m；95%CI 0.00，0.37）和 BIA 体脂肪百分比（β=0.41%；95%CI 0.04，0.77）的增加有关。我们没有观察到性别对效应修饰的证据。