Jackson Sarah E, Kirschbaum Clemens, Steptoe Andrew
Department of Epidemiology and Public Health, University College London, London, UK.
Department of Psychology, Technische Universität Dresden, Dresden, Germany.
Obesity (Silver Spring). 2017 Mar;25(3):539-544. doi: 10.1002/oby.21733.
Chronic cortisol exposure is hypothesized to contribute to obesity. This study examined associations between hair cortisol concentrations, a novel indicator of long-term cortisol exposure, and adiposity in a large population-based sample.
Data were from 2,527 men and women aged 54 and older (98% white British) participating in the English Longitudinal Study of Ageing. Hair cortisol concentrations were determined from the scalp-nearest 2 cm hair segment, and height, weight, and waist circumference were objectively measured. Covariates included age, sex, socioeconomic status, smoking status, diabetes, and arthritis.
In cross-sectional analyses, hair cortisol concentrations were positively correlated with weight (r = 0.102, P < 0.001), BMI (r = 0.101, P < 0.001), and waist circumference (r = 0.082, P = 0.001) and were significantly elevated in participants with obesity (BMI ≥30 kg/m ) (F = 6.58, P = 0.001) and raised waist circumference (≥102 cm in men, ≥88 cm in women) (F = 4.87, P = 0.027). Hair cortisol levels were also positively associated with the persistence of obesity (F = 12.70, P < 0.001), evaluated in retrospect over 4 years.
Chronic exposure to elevated cortisol concentrations, assessed in hair, is associated with markers of adiposity and with the persistence of obesity over time.
据推测，长期暴露于皮质醇会导致肥胖。本研究在一个基于人群的大样本中，检验了头发皮质醇浓度（一种长期皮质醇暴露的新指标）与肥胖之间的关联。
数据来自参与英国老龄化纵向研究的2527名年龄在54岁及以上的男性和女性（98%为英国白人）。从距离头皮最近的2厘米头发段测定头发皮质醇浓度，并客观测量身高、体重和腰围。协变量包括年龄、性别、社会经济地位、吸烟状况、糖尿病和关节炎。
在横断面分析中，头发皮质醇浓度与体重（r = 0.102，P < 0.001）、体重指数（BMI）（r = 0.101，P < 0.001）和腰围（r = 0.082，P = 0.001）呈正相关，在肥胖参与者（BMI≥30 kg/m²）中显著升高（F = 6.58，P = 0.001），在腰围增加者（男性≥102厘米，女性≥88厘米）中也显著升高（F = 4.87，P = 0.027）。回顾4年期间的情况，头发皮质醇水平还与肥胖的持续存在呈正相关（F = 12.70，P < 0.001）。
通过头发评估的长期暴露于升高的皮质醇浓度与肥胖标志物以及肥胖随时间的持续存在有关。
