Zhengzhou University, Zhengzhou, 450001, China.
Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China.
Transl Neurodegener. 2024 Aug 19;13(1):42. doi: 10.1186/s40035-024-00434-9.
Alzheimer's disease (AD) is a progressive neurological disorder that primarily impacts cognitive function. Currently there are no disease-modifying treatments to stop or slow its progression. Recent studies have found that several peripheral and systemic abnormalities are associated with AD, and our understanding of how these alterations contribute to AD is becoming more apparent. In this review, we focuse on amyloid‑beta (Aβ), a major hallmark of AD, summarizing recent findings on the source of brain-derived Aβ and discussing where and how the brain-derived Aβ is cleared in vivo. Based on these findings, we propose future strategies for AD prevention and treatment, from a novel perspective on Aβ metabolism.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，主要影响认知功能。目前尚无能够阻止或减缓其进展的疾病修饰治疗方法。最近的研究发现，几种外周和全身异常与 AD 有关，我们对这些改变如何导致 AD 的认识越来越清楚。在这篇综述中，我们专注于淀粉样蛋白-β（Aβ），它是 AD 的主要标志，总结了关于脑源性 Aβ来源的最新发现，并讨论了脑源性 Aβ在体内的清除位置和方式。基于这些发现，我们从 Aβ代谢的新视角提出了 AD 预防和治疗的未来策略。
