Chen Juejing, Yang Boyu, Cheng Weijing, Liao Yinglin, Jin Ling, Fan Zhiping, Liang Lingyi
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China ; and.
Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China .
Cornea. 2024 Aug 20;44(5):550-558. doi: 10.1097/ICO.0000000000003673.
The purpose of this study was to explore the image characteristics of the palpebral lobe of the lacrimal gland in patients with chronic ocular graft-versus-host disease (coGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) using anterior segment optical coherence tomography (AS-OCT).
This comparative cross-sectional study included 32 patients with coGVHD, 21 patients with severe aqueous tear deficiency dry eye, and 20 healthy control subjects. All subjects underwent an AS-OCT examination on the palpebral lobe of the lacrimal gland. The main outcomes are the number of visible gland lobules, ducts, and blood vessels and the proportions of mille crêpe-like structures in the AS-OCT images.
Compared with the other 2 groups, patients with coGVHD had significantly more blood vessels and slightly less visible lobules and ducts (all P <0.05) in the palpebral lacrimal gland. Mille crêpe-like structures were observed only in the coGVHD group. Number of blood vessels was positively correlated with time after allo-HSCT (β: 0.14, 95% confidence interval [CI], 0.01-0.26). Mille crêpe-like structure was positively correlated with coGVHD severity (odds ratio: 9.07, 95% CI, 1.75-16.38) and time after allo-HSCT (odds ratio: 0.13, 95% CI, 0.03-0.23).
We reported the AS-OCT characteristics of the palpebral lacrimal gland in coGVHD and found an increased number of blood vessels and mille crêpe-like structures. AS-OCT has the potential in the disease monitoring of coGVHD.
本研究旨在利用眼前节光学相干断层扫描（AS-OCT）探讨异基因造血干细胞移植（allo-HSCT）后慢性眼部移植物抗宿主病（coGVHD）患者泪腺睑叶的图像特征。
这项比较性横断面研究纳入了32例coGVHD患者、21例重度水样液缺乏性干眼症患者和20名健康对照者。所有受试者均接受了泪腺睑叶的AS-OCT检查。主要观察指标为AS-OCT图像中可见腺小叶、导管和血管的数量以及千层面饼样结构的比例。
与其他两组相比，coGVHD患者泪腺睑叶中的血管明显更多，可见小叶和导管略少（所有P<0.05）。仅在coGVHD组中观察到千层面饼样结构。血管数量与allo-HSCT后的时间呈正相关（β：0.14，95%置信区间[CI]，0.01-0.26）。千层面饼样结构与coGVHD严重程度呈正相关（比值比：9.07，95%CI，1.75-16.38），与allo-HSCT后的时间呈正相关（比值比：0.13，95%CI，0.03-0.23）。
我们报告了coGVHD患者泪腺睑叶的AS-OCT特征，发现血管数量和千层面饼样结构增加。AS-OCT在coGVHD的疾病监测方面具有潜力。
