Cheng Weijing, Li Longyue, Chen Juejing, Chen Ziyan, Li Jing, Liu Siyi, Zhang Nuan, Gu Feng, Wang Wenhui, Wang Wei, Yang Boyu, Liang Lingyi
Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China.
Sun Yat-Sen University Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Guangzhou, Guangdong, China
Br J Ophthalmol. 2025 Apr 22;109(5):554-560. doi: 10.1136/bjo-2024-325864.
This study aimed to characterise imaging artefacts in the lacrimal gland using swept-source optical coherence tomography (SS-OCT) in patients with dry eye disease (DED) and healthy participants and identify risk factors for these artefacts.
In total, 151 eyes, including 104 from patients with DED and 47 from non-DED participants, were analysed. Demographic data collection, comprehensive ocular examinations and SS-OCT imaging of the palpebral lobe of the lacrimal gland were performed. Artefacts were classified into distinct categories with different severities. Univariate and multivariate logistic regression analyses were performed to evaluate the association of age, gender, best-corrected visual acuity, intraocular pressure (IOP) and the presence of DED with the presence of artefacts.
Eight artefact types and severity grading were defined by analysing 1208 lacrimal SS-OCT images. The three most prevalent artefacts were defocus (75.83%), cliff (67.47%) and Z-off (58.44%). The presence of artefacts was significantly associated with the presence of DED (OR=9.13; 95% CI, 2.39 to 34.88; p=0.001) and higher IOP (OR=1.34; 95% CI, 1.14 to 1.58; p<0.001). Furthermore, multivariate logistic analyses showed that lower tear film breakup time (OR=0.71; 95% CI, 0.55 to 0.92; p=0.009) and higher meibum quality score (OR=2.86; 95% CI, 1.49 to 5.48; p=0.002) were significantly associated with higher odds for the presence of artefacts.
DED eyes had more SS-OCT image artefacts than normal eyes. Stringent standardised image quality control should be implemented before further image analysis when using SS-OCT to assess lacrimal gland image.
本研究旨在利用扫频光学相干断层扫描（SS-OCT）对干眼症（DED）患者和健康参与者的泪腺成像伪像进行特征描述，并确定这些伪像的危险因素。
共分析了151只眼睛，其中包括104只来自DED患者的眼睛和47只来自非DED参与者的眼睛。收集了人口统计学数据，进行了全面的眼部检查，并对泪腺睑叶进行了SS-OCT成像。将伪像分为不同严重程度的不同类别。进行单因素和多因素逻辑回归分析，以评估年龄、性别、最佳矫正视力、眼压（IOP）和DED的存在与伪像存在之间的关联。
通过分析1208张泪腺SS-OCT图像，定义了8种伪像类型和严重程度分级。三种最常见的伪像是散焦（75.83%）、悬崖状（67.47%）和Z轴偏移（58.44%）。伪像的存在与DED的存在（OR=9.13；95%CI，2.39至34.88；p=0.001）和较高的IOP（OR=1.34；95%CI，1.14至1.58；p<0.001）显著相关。此外，多因素逻辑分析表明，较低的泪膜破裂时间（OR=0.71；95%CI，0.55至0.92；p=0.009）和较高的睑板腺质量评分（OR=2.86；95%CI，1.49至5.48；p=0.002）与伪像存在的较高几率显著相关。
DED患者的眼睛比正常眼睛有更多的SS-OCT图像伪像。在使用SS-OCT评估泪腺图像进行进一步图像分析之前，应实施严格的标准化图像质量控制。
