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精神心理宗教治疗对精神分裂症患者脑源性神经营养因子的影响。

Changes in brain-derived neurotrophic factors in schizophrenic patients with spiritual psychoreligious therapy.

机构信息

Program Studi Diploma Keperawatan, Poltekkes Kemenkes Kendari Kendari, Indonesia.

Program Studi Sarjana Terapan Gizi Dan Dietetika, Poltekkes Kemenkes Kendari, Kendari, Indonesia.

出版信息

J Pak Med Assoc. 2024 Aug;74(8):1458-1463. doi: 10.47391/JPMA.10636.

DOI:10.47391/JPMA.10636
PMID:39160713
Abstract

OBJECTIVES

To examine the effect of Spiritual Quranic Emotional Freedom Technique therapy on the level of brain-derived neurotrophic factor in schizophrenic patients.

METHODS

The quasi-experimental study was conducted from August to December 2021 at the Polytechnic of Health, Kendari, Indonesia, and comprised patients of either gender aged >20 years who had been diagnosed with schizophrenia by psychiatrists using the text-revised version of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, had Brief Psychiatric Rating Scale score 50-60, and were part of the treatment programme at the polyclinic. They were divided into experimental group A and control group B. Patients in group A were given 30 days of Spiritual Quranic Emotional Freedom Technique therapy, while those in group B received only education about the spiritual therapy with the recommendation to listen to the Quran verses. A set of healthy controls memorizing the Quran was enrolled from the Islamic Boarding School, Kendari, and placed in group C. They were given education about the need to keep reading and learning the Quran. The intervention was done 2 times per week for 4 weeks. Serum brain-derived neurotrophic factor level for all groups and the Brief Psychiatric Rating Scale score for groups A and B were assessed at baseline and post-intervention. Data was analysed using SPSS 22.

RESULTS

Of the 30 subjects, 16(53.3%) were females and 14(46.7%) were males. There were 11(36.7%) subjects aged 31-40 years. Each of the 3 groups had 10(33.3%) subjects. There was a significant decrease in Brief Psychiatric Rating Scale scores in groups A and B post-intervention (p<0.000). There was a significant increase in serum brain-derived neurotrophic factor levels post-therapy in groups A and C (p<0.001), while in group B it was not significant (p=0.500).

CONCLUSIONS

Spiritual Quranic Emotional Freedom Technique therapy could enhance clinical improvement and brain function in schizophrenic patients.

摘要

目的

研究精神古兰经情绪自由技术疗法对精神分裂症患者脑源性神经营养因子水平的影响。

方法

本准实验研究于 2021 年 8 月至 12 月在印度尼西亚肯达里卫生理工学院进行,纳入了由精神科医生使用第四版《精神障碍诊断与统计手册》文字修订版诊断为精神分裂症、简明精神病评定量表评分 50-60 分且正在综合诊所接受治疗的、性别不限的年龄>20 岁的患者。他们被分为实验组 A 和对照组 B。实验组 A 患者接受 30 天的精神古兰经情绪自由技术疗法,而对照组 B 患者仅接受有关精神疗法的教育,并建议他们听古兰经经文。从肯达里伊斯兰寄宿学校招募了一组记忆古兰经的健康对照组,并将其纳入组 C。他们接受了有关需要继续阅读和学习古兰经的教育。干预措施每周进行 2 次,共进行 4 周。在基线和干预后评估所有组的血清脑源性神经营养因子水平以及组 A 和 B 的简明精神病评定量表评分。使用 SPSS 22 进行数据分析。

结果

30 名受试者中,女性 16 名(53.3%),男性 14 名(46.7%)。年龄在 31-40 岁的受试者有 11 名(36.7%)。每组有 10 名(33.3%)受试者。干预后,组 A 和 B 的简明精神病评定量表评分显著下降(p<0.000)。组 A 和 C 治疗后血清脑源性神经营养因子水平显著升高(p<0.001),而组 B 则无显著变化(p=0.500)。

结论

精神古兰经情绪自由技术疗法可改善精神分裂症患者的临床症状和大脑功能。

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