Feizi T
Cancer Surv. 1985;4(1):245-69.
Studies with naturally occurring and hybridoma-derived monoclonal antibodies have shown that surface and secreted antigens which distinguish human tumour cells from their normal counterparts are predominantly carbohydrate structures. Many of these belong to a family which includes the major blood-group antigens. In fact, the blood-group genes and the related secretor gene account for the individual and tissue-specific patterns of expression of several carbohydrate antigens as normal or as tumour-associated antigens. The biochemical basis of the tumour-associated changes requires investigation. In particular, it will be important to determine whether they are the result of aberrant expression of the glycosyltransferase genes. Their contribution to the disordered growth regulation in tumour cells will also be important to assess, particularly as the blood group family of oligosaccharides are among major antigenic components of the receptor for epidermal growth factor. Monoclonal antibodies to carbohydrate structures have opened new avenues of research into the biochemistry of tumour cells.
对天然存在的和杂交瘤衍生的单克隆抗体的研究表明，区分人类肿瘤细胞与其正常对应物的表面和分泌抗原主要是碳水化合物结构。其中许多属于一个家族，包括主要的血型抗原。事实上，血型基因和相关的分泌基因决定了几种碳水化合物抗原作为正常或肿瘤相关抗原的个体和组织特异性表达模式。肿瘤相关变化的生化基础需要研究。特别是，确定它们是否是糖基转移酶基因异常表达的结果将很重要。评估它们对肿瘤细胞中生长调节紊乱的作用也很重要，尤其是因为寡糖的血型家族是表皮生长因子受体的主要抗原成分之一。针对碳水化合物结构的单克隆抗体为肿瘤细胞生物化学的研究开辟了新途径。
