Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, China.
College of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
J Clin Hypertens (Greenwich). 2024 Oct;26(10):1155-1162. doi: 10.1111/jch.14885. Epub 2024 Aug 19.
This was a retrospective study. This study investigated the occurrence of a composite endpoints (cardiovascular and cerebrovascular events, end-stage renal disease, and death) in 153 patients (aged ≥ 18 years) with a diagnosis of in chronic kidney disease (CKD). Based on morning blood pressure surge (MBPS) defined as ≥35 mm Hg, patients were divided into two groups: with MBPS (n = 50) and without MBPS (n = 103). All patients were followed up for at least 1 year. Baseline demographic, laboratory and follow-up data were collected. The clinical characteristics of the two groups were compared. The relationships between MBPS and endpoint events were analyzed using the Kaplan-Meier method and Cox regression model. In total, 153 patients (mean age 41.8 years; 56.86% males) were included in this study. During the follow-up period (mean 4.3 years), 34 endpoint events occurred. After adjustment for the covariates, the risk of cardiovascular and cerebrovascular events, end-stage renal disease and death remained significantly higher in patients with MBPS (hazard ratio [HR] and 95% confidence interval [CI] 3.124 [1.096-9.130]]) Among the other variables, systolic blood pressure, and night-time and daytime pulse pressures remained significantly associated with outcome in patients of CKD (1.789 [1.205-2.654], 1.710 [1.200-2.437], and 1.318 [1.096-1.586], respectively]. In conclusions, MBPS was identified as an independent prognostic factor for composite endpoint events (cardiovascular and cerebrovascular events, end-stage renal disease and death) patients with chronic kidney disease patients.
这是一项回顾性研究。本研究调查了 153 例慢性肾脏病（CKD）患者（年龄≥18 岁）复合终点事件（心血管和脑血管事件、终末期肾病和死亡）的发生情况。根据定义为≥35mmHg 的清晨血压激增（MBPS），将患者分为两组：有 MBPS（n=50）和无 MBPS（n=103）。所有患者均至少随访 1 年。收集基线人口统计学、实验室和随访数据。比较两组的临床特征。采用 Kaplan-Meier 法和 Cox 回归模型分析 MBPS 与终点事件的关系。共有 153 例患者（平均年龄 41.8 岁；56.86%为男性）纳入本研究。在随访期间（平均 4.3 年），发生 34 例终点事件。在校正协变量后，MBPS 患者发生心血管和脑血管事件、终末期肾病和死亡的风险仍然显著升高（风险比[HR]和 95%置信区间[CI]为 3.124[1.096-9.130]）。在其他变量中，收缩压以及夜间和日间脉压与 CKD 患者的结局仍显著相关（1.789[1.205-2.654]、1.710[1.200-2.437]和 1.318[1.096-1.586]）。总之，MBPS 是慢性肾脏病患者复合终点事件（心血管和脑血管事件、终末期肾病和死亡）的独立预后因素。
