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澳大利亚音乐节的新型减少伤害措施:澳大利亚维多利亚新兴毒品网络毒情监测方法的试点实施。

Novel harm reduction measures at music festivals in Australia: Pilot implementation of the Emerging Drugs Network of Australia-Victoria toxicosurveillance methodology.

机构信息

Department of Forensic Medicine, Monash University, Melbourne, Australia.

Victorian Poisons Information Centre, Austin Hospital, Austin Health, Melbourne, Australia.

出版信息

Drug Alcohol Rev. 2024 Nov;43(7):2045-2054. doi: 10.1111/dar.13922. Epub 2024 Aug 19.

Abstract

INTRODUCTION

Harm reduction strategies at music festivals seek to create a safer environment for patrons. The Emerging Drugs Network of Australia-Victoria (EDNAV) project is a state-wide toxicosurveillance network that derives drug intelligence from a sample of patients presenting to hospital with illicit drug-related toxicity. This publication describes the preliminary outcomes of conducting toxicosurveillance for critically unwell festival patrons within on-site medical facilities.

METHODS

Blood samples were collected from patrons who presented with severe illicit drug-related toxicity across three festivals (2022/2023). Blood samples were analysed via liquid chromatography-tandem mass spectrometry for over 700 pharmaceutical and illicit drugs.

RESULTS

There were 1603 individual medical encounters across the festivals, 228 of which were illicit drug related. A blood sample was collected for 24 patients, with a median age of 22 years (range 18-39 years). A median of two drugs (range 1-5 drugs) were reported and four drugs (range 0-8 drugs) were analytically confirmed per patient. The most frequently reported exposures were congruent with analytical results, 3,4-methylenedioxymethamphetamine (reported n = 17, detected n = 20), ketamine (reported n = 9, detected n = 13) and cocaine (reported n = 9, detected n = 12). An unreported illicit drug and/or new psychoactive substance (NPS) was detected in 18 patients, including methylamphetamine (n = 10), a cathinone (n = 7), benzodiazepine-type NPS (n = 6), N-ethylamphetamine (n = 1), 3-hydroxyphencyclidine (n = 1) and/or 4-hydroxy-N-methyl-N-isopropyltryptamine (n = 1).

DISCUSSION AND CONCLUSIONS

EDNAV toxicosurveillance serves as an additional tool within a multi-faceted approach to harm reduction at festivals. Continued data collection will allow for the characterisation of high-risk drug use patterns to provide evidence-based messaging to festival patrons and key stakeholders.

摘要

简介

音乐节上的减少伤害策略旨在为顾客创造更安全的环境。澳大利亚维多利亚新兴毒品网络(EDNAV)项目是一个全州范围的毒情监测网络,从因非法药物相关毒性到医院就诊的患者样本中获取药物情报。本出版物描述了在现场医疗设施中对病情严重的音乐节顾客进行毒情监测的初步结果。

方法

从在三个音乐节(2022/2023 年)出现严重非法药物相关毒性的顾客身上采集血样。通过液相色谱-串联质谱法对超过 700 种药物和非法药物进行分析。

结果

在整个音乐节期间,共有 1603 名患者接受了治疗,其中 228 人是非法药物相关的。对 24 名患者采集了血样,中位数年龄为 22 岁(范围为 18-39 岁)。每位患者报告的药物中位数为 2 种(范围为 1-5 种),分析确认的药物中位数为 4 种(范围为 0-8 种)。最常报告的暴露情况与分析结果一致,3,4-亚甲二氧基甲基苯丙胺(报告 n=17,检测 n=20)、氯胺酮(报告 n=9,检测 n=13)和可卡因(报告 n=9,检测 n=12)。在 18 名患者中检测到一种未报告的非法药物和/或新精神活性物质(NPS),包括甲基苯丙胺(n=10)、一种卡西酮(n=7)、苯并二氮䓬类 NPS(n=6)、N-乙基苯丙胺(n=1)、3-羟基苯环利定(n=1)和/或 4-羟基-N-甲基-N-异丙基色胺(n=1)。

讨论和结论

EDNAV 毒情监测是音乐节减少伤害多方面方法的一个额外工具。继续收集数据将允许对高危药物使用模式进行特征描述,为音乐节顾客和主要利益相关者提供基于证据的信息。

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