Ma Yijie, Yang Yiwen, Zhang Huizhi, Mugaanyi Joseph, Hu Yangke, Wu Shengdong, Lu Caide, Mao Shuqi, Wang Ke
Department of Hepatobiliary Pancreatic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang 315048, P.R. China.
Oncol Lett. 2024 Aug 5;28(4):477. doi: 10.3892/ol.2024.14610. eCollection 2024 Oct.
Sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive subtype of undifferentiated pancreatic ductal adenocarcinoma, with a generally poor prognosis and only sporadic cases reported worldwide. Histologically, the most notable feature of SCP is the presence of abundant of mesenchymatoid spindle tumor cells in the tumor, which lack glandular differentiation. Immunohistochemically, SCP is characterized by the expression of both mesenchymal and epithelial markers. With only a few reported cases, there is limited knowledge about its molecular and clinicopathological characteristics. Therefore, the present study performed a literature search to identify all relevant published studies. The present review provides an overview of the histogenesis, diagnosis, genetic features, prognosis and treatment of SCP, specifically focusing on the molecular alterations. Furthermore, a single-center experience is reported, which adds to the limited evidence available in the literature.
胰腺肉瘤样癌（SCP）是未分化胰腺导管腺癌的一种罕见且侵袭性强的亚型，预后通常较差，全球仅报道过散发病例。组织学上，SCP最显著的特征是肿瘤中存在大量间充质样梭形肿瘤细胞，缺乏腺管分化。免疫组化方面，SCP的特征是同时表达间充质和上皮标志物。由于报道的病例较少，对其分子和临床病理特征的了解有限。因此，本研究进行了文献检索以识别所有相关的已发表研究。本综述概述了SCP的组织发生、诊断、基因特征、预后和治疗，特别关注分子改变。此外，还报告了单中心经验，这增加了文献中有限的证据。
