Kong Xiangyang, Yang Junjie, Jiang Yiqian
Department of Radiotherapy, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China.
Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China.
Oncol Lett. 2024 Aug 8;28(4):484. doi: 10.3892/ol.2024.14618. eCollection 2024 Oct.
Combined large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC) is extremely rare, with only a few reports available in the literature. An accurate diagnosis is difficult to make due to the overlapping clinical features between LCNEC and SCLC, and a standardized treatment option is lacking. A 53-year-old female patient was admitted to Xiaoshan Affiliated Hospital of Wenzhou Medical University (Hangzhou, China) due to symptoms of dyspnea and phlegm, with blood in the sputum. Computed tomography revealed a 52×32×26-mm irregular soft-tissue mass in the left upper lung. Pathological examination of the biopsy specimen showed a poorly differentiated neuroendocrine carcinoma with compression injury, consistent with a mixed type of large and small cell carcinoma. The patient was administered chemotherapy, radiotherapy and targeted therapy, and as of October 2023, the patient had a survival period of 29 months. LCNEC combined with SCLC is a sporadic tumor with a high potential for malignancy. Multidisciplinary treatment and close follow-up are recommended. The multidisciplinary treatment strategy used in the present study is expected to help inform future therapeutic decisions.
大细胞神经内分泌癌（LCNEC）与小细胞肺癌（SCLC）合并极为罕见，文献中仅有少数报道。由于LCNEC和SCLC之间临床特征重叠，难以做出准确诊断，且缺乏标准化的治疗方案。一名53岁女性患者因呼吸困难、咳痰伴痰中带血入住温州医科大学附属萧山医院（中国杭州）。计算机断层扫描显示左上肺有一个52×32×26毫米的不规则软组织肿块。活检标本的病理检查显示为低分化神经内分泌癌伴压迫性损伤，符合大细胞和小细胞混合型癌。该患者接受了化疗、放疗和靶向治疗，截至2023年10月，患者生存期为29个月。LCNEC合并SCLC是一种散发性肿瘤，恶性潜能高。建议采用多学科治疗并密切随访。本研究中使用的多学科治疗策略有望为未来的治疗决策提供参考。
