Li Shuang, Huo Chenlu, Liu Anting, Zhu Yan
Graduate School of Anhui University of Chinese Medicine, Hefei, Anhui, China.
Department of Geriatrics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
Front Med (Lausanne). 2024 Aug 5;11:1439182. doi: 10.3389/fmed.2024.1439182. eCollection 2024.
As a chronic autoimmune disease with complex aetiology, rheumatoid arthritis (RA) has been demonstrated to be associated with mitochondrial dysfunction since mitochondrial dysfunction can affect the survival, activation, and differentiation of immune and non-immune cells involved in the pathogenesis of RA. Nevertheless, the mechanism behind mitochondrial dysfunction in RA remains uncertain. Accordingly, this review addresses the possible role and mechanisms of mitochondrial dysfunction in RA and discusses the potential and challenges of mitochondria as a potential therapeutic strategy for RA, thereby providing a breakthrough point in the prevention and treatment of RA.
类风湿关节炎（RA）作为一种病因复杂的慢性自身免疫性疾病，已被证明与线粒体功能障碍有关，因为线粒体功能障碍会影响参与RA发病机制的免疫和非免疫细胞的存活、激活和分化。然而，RA中线粒体功能障碍背后的机制仍不明确。因此，本综述探讨了线粒体功能障碍在RA中的可能作用和机制，并讨论了线粒体作为RA潜在治疗策略的潜力和挑战，从而为RA的预防和治疗提供一个突破点。
