Liang Chengzhi, Fan Zaiwei, Zhang Zirui, Wang Pinkai, Deng Hui, Tao Jun
Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330000 China
Department of Rehabilitation Medicine, The 960th Hospital of the Chinese People's Liberation Army Jinan 250000 China.
RSC Adv. 2024 Aug 19;14(36):26077-26090. doi: 10.1039/d4ra04043k. eCollection 2024 Aug 16.
The regeneration of tendon-bone interface tissue has become a topic of great interest in recent years. However, the complex nature of this interface has posed challenges in finding suitable solutions. Tissue engineering, with its potential to improve clinical outcomes and play a crucial role in musculoskeletal function, has been increasingly explored for tendon-bone interface regeneration. This review focuses on the research advancements of electrospinning technology in interface tissue engineering. By utilizing electrospinning, researchers have been able to fabricate scaffolds with tailored properties to promote the regeneration and integration of tendon and bone tissues. The review discusses the unique structure and function of the tendon-bone interface, the mechanisms involved in its healing, and the limitations currently faced in achieving successful regeneration. Additionally, it highlights the potential of electrospinning technology in scaffold fabrication and its role in facilitating the development of functional and integrated tendon-bone interface tissues. Overall, this review provides valuable insights into the application of electrospinning technology for tendon-bone interface tissue engineering, emphasizing its significance in addressing the challenges associated with regeneration in this complex interface.
近年来,肌腱-骨界面组织的再生已成为一个备受关注的话题。然而,该界面的复杂性给寻找合适的解决方案带来了挑战。组织工程具有改善临床结果并在肌肉骨骼功能中发挥关键作用的潜力,因此越来越多地被用于肌腱-骨界面再生的研究。本综述重点关注静电纺丝技术在界面组织工程中的研究进展。通过使用静电纺丝技术,研究人员能够制造出具有定制特性的支架,以促进肌腱和骨组织的再生与整合。综述讨论了肌腱-骨界面的独特结构和功能、其愈合过程中涉及的机制以及目前在实现成功再生方面面临的局限性。此外,还强调了静电纺丝技术在支架制造中的潜力及其在促进功能性和整合性肌腱-骨界面组织发育中的作用。总体而言,本综述为静电纺丝技术在肌腱-骨界面组织工程中的应用提供了有价值的见解,强调了其在应对这一复杂界面再生相关挑战方面的重要性。