Wang Qun, Ji Peng, Bu Tian, Mao Yating, He Hailun, Ge Naijing
School of Chemistry, Chemical and Materials Engineering, Taizhou University, Taizhou 225300, China.
School of Pharmacy, Taizhou University, Taizhou 225300, China.
J Funct Biomater. 2025 Jul 18;16(7):266. doi: 10.3390/jfb16070266.
Electrospinning has emerged as a highly effective technique for fabricating micro- and nanofibers, which are characterized by high porosity, large surface area, and structural mimicry of the extracellular matrix (ECM). These properties render it particularly suitable for biomedical applications. This review provides a comprehensive overview of recent developments in electrospinning-based strategies across various biomedical fields, including tissue engineering, drug delivery, wound healing, enzyme immobilization, biosensing, and protective materials. The distinctive advantages of electrospun fibers-such as excellent biocompatibility, tunable architecture, and facile surface functionalization-are discussed, alongside challenges such as the toxicity of organic solvents and limitations in scalability. Emerging approaches, including environmentally benign electrospinning techniques and integration with advanced technologies such as 3D printing and microfluidics, present promising solutions for intelligent and personalized biomedical applications.
静电纺丝已成为一种用于制造微纤维和纳米纤维的高效技术，这些纤维具有高孔隙率、大表面积以及细胞外基质（ECM）结构模拟的特点。这些特性使其特别适用于生物医学应用。本综述全面概述了基于静电纺丝的策略在各个生物医学领域的最新进展，包括组织工程、药物递送、伤口愈合、酶固定化、生物传感和防护材料。讨论了静电纺丝纤维的独特优势，如优异的生物相容性、可调节的结构和易于进行表面功能化，同时也探讨了诸如有机溶剂毒性和可扩展性限制等挑战。新兴方法，包括环境友好型静电纺丝技术以及与3D打印和微流体等先进技术的整合，为智能和个性化生物医学应用提供了有前景的解决方案。
