Chai Hua, Wei Yanru, Chen Wenguang, Han Guorui, Godspower Bello-Onaghise, Liu Yanyan, Dong Chunliu, Zhang Zhiyun, Li Yanhua
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Department of Animal Science, Faculty of Agriculture, University of Benin, Benin City, Nigeria.
Front Vet Sci. 2024 Aug 5;11:1436426. doi: 10.3389/fvets.2024.1436426. eCollection 2024.
The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) poses a significant threat to the global swine industry. Vaccination is a preventive measure against viral infections. However, the use of vaccines in livestock healthcare programs faces the challenge of safety and delayed immune responses. Earlier studies have shown the potential of modified Bazhen powder as an immunomodulator with significant biological properties, but its effect on vaccines against HP-PRRSV is yet to be studied. This study elucidated how modified Bazhen powder could improve the safety and efficacy of the conventional PRRSV vaccine by evaluating T-cell responses, antibody levels, clinical symptoms, levels of viremia, organ health, and cytokine production. The results revealed that the oral application of modified Bazhen powder in combination with PRRS vaccination improved both cellular and humoral immunity, accelerated viremia clearance, improved lung injury scores, and reduced viral load in the tonsils. The modified Bazhen powder also effectively reduced inflammatory responses following a PRRSV challenge. These findings further highlight the pharmacological properties of modified Bazhen powder as a potential oral immunomodulatory agent that could enhance vaccine efficacy and ensure broad-spectrum protection against HP-PRRSV in pigs.
高致病性猪繁殖与呼吸综合征病毒（HP-PRRSV）对全球养猪业构成重大威胁。疫苗接种是预防病毒感染的一项措施。然而，在牲畜保健计划中使用疫苗面临安全性和免疫反应延迟的挑战。早期研究表明，加味八珍散作为一种具有显著生物学特性的免疫调节剂具有潜力，但其对HP-PRRSV疫苗的作用尚待研究。本研究通过评估T细胞反应、抗体水平、临床症状、病毒血症水平、器官健康状况和细胞因子产生，阐明了加味八珍散如何提高传统PRRSV疫苗的安全性和有效性。结果显示，加味八珍散与PRRS疫苗联合口服应用可改善细胞免疫和体液免疫，加速病毒血症清除，提高肺损伤评分，并降低扁桃体中的病毒载量。加味八珍散还能有效减轻PRRSV攻击后的炎症反应。这些发现进一步突出了加味八珍散作为一种潜在的口服免疫调节剂的药理特性，其可提高疫苗效力并确保对猪的HP-PRRSV具有广谱保护作用。
