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费尔蒂综合征的非典型表现：利妥昔单抗治疗成功——病例报告及文献综述

Atypical presentation of Felty syndrome: Successful management with rituximab therapy-A case report and review of literature.

作者信息

Iqbal Rabia, Colon-Ramos Ana, Hysenaj Zhenisa, Sinha Samridhi, Nabi Shahzaib, Marowa Sabrin

机构信息

Department of Internal Medicine The Brooklyn Hospital Center Brooklyn New York USA.

Department of Hematology and Oncology The Brooklyn Hospital Center Brooklyn New York USA.

出版信息

Clin Case Rep. 2024 Aug 18;12(8):e9339. doi: 10.1002/ccr3.9339. eCollection 2024 Aug.

DOI:10.1002/ccr3.9339
PMID:39161674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11331027/
Abstract

The atypical presentation of Felty syndrome, even without arthritis symptoms, needs further evaluation. Timely diagnosis of neutropenia and splenomegaly in patients with rheumatoid arthritis without joint symptoms is crucial for a better prognosis. Despite the rarity of the condition, clinicians should have a high index of suspicion, and multidisciplinary collaboration between rheumatology, hematology, and other specialists is required for accurate diagnosis.

摘要

费尔蒂综合征的非典型表现，即使没有关节炎症状，也需要进一步评估。对于没有关节症状的类风湿关节炎患者，及时诊断中性粒细胞减少和脾肿大对于改善预后至关重要。尽管这种情况罕见，但临床医生应保持高度怀疑，准确诊断需要风湿病学、血液学和其他专科之间的多学科协作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/79658017d157/CCR3-12-e9339-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/678bd213d166/CCR3-12-e9339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/92105341576e/CCR3-12-e9339-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/79658017d157/CCR3-12-e9339-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/678bd213d166/CCR3-12-e9339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/92105341576e/CCR3-12-e9339-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c9/11331027/79658017d157/CCR3-12-e9339-g003.jpg

相似文献

1
Atypical presentation of Felty syndrome: Successful management with rituximab therapy-A case report and review of literature.费尔蒂综合征的非典型表现：利妥昔单抗治疗成功——病例报告及文献综述
Clin Case Rep. 2024 Aug 18;12(8):e9339. doi: 10.1002/ccr3.9339. eCollection 2024 Aug.
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本文引用的文献

1
The Diagnosis Felt(y) Right: A Case Report of Felty Syndrome With Limited Articular Involvement.诊断“感觉”正确：1例关节受累有限的费尔蒂综合征病例报告
Cureus. 2022 Apr 29;14(4):e24593. doi: 10.7759/cureus.24593. eCollection 2022 Apr.
2
Non-Articular Felty Syndrome Refractory to Granulocyte Colony-Stimulating Factor Therapy.粒细胞集落刺激因子治疗无效的非关节型费尔蒂综合征
Cureus. 2021 Aug 15;13(8):e17206. doi: 10.7759/cureus.17206. eCollection 2021 Aug.
3
Felty syndrome: a case report.费尔蒂综合征：一例报告。
J Med Case Rep. 2021 May 27;15(1):273. doi: 10.1186/s13256-021-02802-9.
4
Efficacy and safety of rituximab for autoimmune neutropenia: a French case series and literature review.利妥昔单抗治疗自身免疫性中性粒细胞减少症的疗效与安全性：一项法国病例系列研究及文献综述
Rheumatology (Oxford). 2020 Sep 1;59(9):2637-2640. doi: 10.1093/rheumatology/keaa045.
5
Neutropaenia and splenomegaly without arthritis: think rheumatoid arthritis.无关节炎的中性粒细胞减少和脾肿大：考虑类风湿关节炎。
BMJ Case Rep. 2018 Jul 11;2018:bcr-2018-225359. doi: 10.1136/bcr-2018-225359.
6
Non-articular Felty's syndrome: An uncommon diagnosis.非关节型费尔蒂综合征：一种罕见的诊断。
Neth J Med. 2015 Nov;73(9):435-6.
7
Severe extra-articular manifestations of rheumatoid arthritis in absence of concomitant joint involvement following long-term spontaneous remission. A case report.长期自发缓解后无关节受累情况下类风湿关节炎的严重关节外表现。病例报告。
Reumatol Clin. 2016 Jul-Aug;12(4):223-5. doi: 10.1016/j.reuma.2015.07.006. Epub 2015 Aug 24.
8
A beneficial long-term and consistent response to rituximab in the treatment of refractory neutropenia and arthritis in a patient with Felty syndrome.利妥昔单抗治疗费尔蒂综合征患者难治性中性粒细胞减少症和关节炎取得长期持续有益反应。
J Clin Rheumatol. 2014 Oct;20(7):398. doi: 10.1097/RHU.0000000000000175.
9
Felty's syndrome without rheumatoid arthritis?费尔蒂综合征而无类风湿关节炎？
Clin Rheumatol. 2013 May;32(5):701-4. doi: 10.1007/s10067-012-2157-3. Epub 2013 Jan 5.
10
Biological agents in the management of Felty's syndrome: a systematic review.生物制剂在费尔蒂综合征治疗中的应用：系统评价。
Semin Arthritis Rheum. 2012 Apr;41(5):658-68. doi: 10.1016/j.semarthrit.2011.08.008. Epub 2011 Nov 25.