Song Yeonsu, Martin Jennifer L, McCurry Susan M, Kelly Monica R, Teng Edmond, Alessi Cathy A, Irwin Michael R, Cole Steve
School of Nursing, University of California, Los Angeles, Los Angeles, CA, USA.
Geriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, North Hills, CA, USA.
Sleep Adv. 2024 Jul 25;5(1):zpae052. doi: 10.1093/sleepadvances/zpae052. eCollection 2024.
Poor sleep is associated with increased inflammation, thereby increasing the risk of chronic diseases and mortality. However, the effects of behavioral sleep interventions on the upstream inflammatory system are unknown among family care partners (CP). The present study explored the role of a behavioral sleep intervention program on inflammatory gene expression.
This was part of a randomized controlled trial of a sleep intervention for dementia care dyads with sleep problems. Thirty dyads were randomized to sleep intervention or control groups. Sleep outcomes for CP were assessed with 1 week of actigraphy and sleep diary, and the Pittsburgh Sleep Quality Index. Other information included CP demographics, body mass index, and intensity of caregiving tasks. All outcomes were collected at baseline, post-treatment, and 3-month follow-up.
Neither group showed any significant differential changes in gene expression from baseline to post-treatment or 3-month follow-up. A decrease in inflammatory gene expression was significantly associated with more nights of good sleep (i.e. nights without trouble falling or staying asleep at night). This finding remained significant after controlling for group (intervention/control), timepoint (baseline, post-treatment, and 3-month follow-up), and CP characteristics (e.g. age and ethnicity).
Although better sleep was associated with decreased inflammatory gene expression, this study did not demonstrate any benefits of a behavioral sleep intervention over control, most likely due to a small sample. Studies with larger sample sizes are needed to test the specific aspects of disturbed sleep that relate to inflammatory biology among CP of persons living with dementia.
睡眠不佳与炎症增加相关，从而增加患慢性病和死亡的风险。然而，行为睡眠干预对家庭护理伙伴（CP）上游炎症系统的影响尚不清楚。本研究探讨了行为睡眠干预计划对炎症基因表达的作用。
这是一项针对有睡眠问题的痴呆症护理二元组进行睡眠干预的随机对照试验的一部分。30个二元组被随机分为睡眠干预组或对照组。通过1周的活动记录仪和睡眠日记以及匹兹堡睡眠质量指数对CP的睡眠结果进行评估。其他信息包括CP的人口统计学特征、体重指数和护理任务强度。所有结果均在基线、治疗后和3个月随访时收集。
从基线到治疗后或3个月随访，两组在基因表达上均未显示出任何显著的差异变化。炎症基因表达的降低与更多的良好睡眠夜晚（即夜间入睡或保持睡眠无困难的夜晚）显著相关。在控制了组（干预/对照）、时间点（基线、治疗后和3个月随访）和CP特征（如年龄和种族）后，这一发现仍然显著。
尽管更好的睡眠与炎症基因表达降低相关，但本研究并未证明行为睡眠干预比对照组有任何益处，这很可能是由于样本量较小。需要更大样本量的研究来测试与痴呆症患者CP中炎症生物学相关的睡眠障碍的具体方面。
