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HIV治疗引发的免疫重建炎症综合征作为潜在诱因：一例迟发性发作性睡病的病例报告

Immune Reconstitution Inflammatory Syndrome Due to HIV Treatment as a Potential Trigger: A Case Report with Late-Onset Narcolepsy.

作者信息

Yu Jiaqin, Shen Ting, Li Zongshan, Lv Tian, Zhang Lisan

机构信息

School of Medicine, Shaoxing University, Shaoxing, Zhejiang, People's Republic of China.

Department of Neurology, Zhuji People's Hospital of Zhejiang Province, Zhuji, People's Republic of China.

出版信息

Nat Sci Sleep. 2024 Aug 15;16:1213-1217. doi: 10.2147/NSS.S476922. eCollection 2024.

DOI:10.2147/NSS.S476922
PMID:39161889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11332423/
Abstract

Narcolepsy type 1 (NT1) is a unique central sleepiness disorder that affects individuals with excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, and hypnagogic hallucinations. The etiology and pathogenesis of NT1 remains unclear, although some viral infections are thought to be related to NT1. This paper reports an unusual case of late-onset NT1 with human immunodeficiency virus (HIV) infection and antiretroviral therapy for five years. The relationship between HIV infection, immune, Immune reconstitution inflammatory syndrome (IRIS) and NT1 should be further investigated, as excessive daytime sleepiness is more common in HIV-infected patients than in the general population.

摘要

1型发作性睡病（NT1）是一种独特的中枢性嗜睡障碍，影响着有日间过度嗜睡（EDS）、猝倒、睡眠麻痹和入睡前幻觉的个体。尽管一些病毒感染被认为与NT1有关，但NT1的病因和发病机制仍不清楚。本文报告了一例罕见的迟发性NT1病例，该患者感染了人类免疫缺陷病毒（HIV）并接受了五年的抗逆转录病毒治疗。由于日间过度嗜睡在HIV感染患者中比在普通人群中更常见，因此应进一步研究HIV感染、免疫、免疫重建炎症综合征（IRIS）与NT1之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dc7/11332423/d43f502a0c55/NSS-16-1213-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dc7/11332423/eeba0cde5462/NSS-16-1213-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dc7/11332423/d43f502a0c55/NSS-16-1213-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dc7/11332423/eeba0cde5462/NSS-16-1213-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dc7/11332423/d43f502a0c55/NSS-16-1213-g0002.jpg

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