Martens Julie, Van Den Bossche Maarten
Geriatric Psychiatry, University Psychiatric Center KU Leuven, Leuven, Belgium.
Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
J Clin Sleep Med. 2025 May 1;21(5):917-929. doi: 10.5664/jcsm.11540.
Narcolepsy type 1 is a clinical syndrome defined by recurrent episodes of excessive daytime sleepiness, episodes of cataplexy, hypnagogic hallucinations, and sleep paralysis. Symptoms typically manifest in the second or third decade with another small peak in the fourth decade. In this report we describe the case of a 64-year-old female presenting with new-onset visual hallucinations as the main complaint. Eventually diagnosis of narcolepsy type 1 was confirmed by determination of orexin levels (hypocretin-1) on cerebrospinal fluid. This case illustrates that age of onset of narcolepsy type 1 can be as late as the sixth decade in life and that narcolepsy type 1 should be considered as a possible though rare diagnosis in older adults presenting with new onset neuropsychiatric symptoms like visual hallucinations.
Martens J, Van Den Bossche M. Very late onset narcolepsy type 1: a case report and review of the literature. . 2025;21(5):917-929.
发作性睡病1型是一种临床综合征，其特征为反复发作的日间过度嗜睡、猝倒发作、入睡前幻觉和睡眠瘫痪。症状通常在第二个或第三个十年出现，在第四个十年有另一个小高峰。在本报告中，我们描述了一例以新发视幻觉为主要主诉的64岁女性病例。最终通过测定脑脊液中食欲素水平（下丘脑分泌素-1）确诊为发作性睡病1型。该病例表明，发作性睡病1型的发病年龄可晚至第六个十年，对于出现新发视幻觉等神经精神症状的老年人，应考虑发作性睡病1型这一可能但罕见的诊断。
Martens J, Van Den Bossche M. 非常晚发的发作性睡病1型：一例病例报告及文献综述。. 2025;21(5):917 - 929。
