Li Ying, Yang Jintao, Zheng Bei, Yan Na, Yang Wenjuan, Xie Xinling, Xu Guoshu, Zhang Meiling
Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
SAGE Open Med Case Rep. 2024 Aug 16;12:2050313X241271818. doi: 10.1177/2050313X241271818. eCollection 2024.
Malignant peritoneal mesothelioma is an exceedingly rare malignant tumor. Herein, we present a case of malignant peritoneal mesothelioma in a 59-year-old Chinese female patient who was stable after treatment for multiple relapses. Imaging revealed massive ascites and an irregular thickening of the peritoneal mesangium. Laparoscopic biopsy revealed heterogeneous cell nests in the parietal peritoneal fibrous tissue, which were confirmed by immunohistochemical staining for Calretinin, WT-1, and D2-40. In terms of genetic screening, , and other key driver gene variants closely related to malignant peritoneal mesothelioma have been explored in tumor tissues. Notably, driver mutation was first found in all malignant peritoneal mesothelioma patients, and A1159T gene mutation found in recurrent focal tissue may be associated with recurrent tumor recurrence.
恶性腹膜间皮瘤是一种极其罕见的恶性肿瘤。在此，我们报告一例59岁中国女性恶性腹膜间皮瘤患者，该患者在多次复发治疗后病情稳定。影像学检查显示大量腹水和腹膜系膜不规则增厚。腹腔镜活检显示壁层腹膜纤维组织中有异质性细胞巢，通过钙视网膜蛋白、WT-1和D2-40免疫组化染色得以证实。在基因筛查方面，已在肿瘤组织中探索了与恶性腹膜间皮瘤密切相关的 以及其他关键驱动基因变异。值得注意的是，在所有恶性腹膜间皮瘤患者中首次发现了 驱动突变，在复发病灶组织中发现的A1159T基因突变可能与肿瘤复发有关。
