Lou Xin-Yue, Zhang Kun, Bai Yujie, Zhang Siyuan, Li Yuanyuan, Yang Ying-Wei
College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, 5333 Xi'an Street, Changchun, 130062, China.
Angew Chem Int Ed Engl. 2025 Jan 10;64(2):e202414611. doi: 10.1002/anie.202414611. Epub 2024 Oct 17.
Helical nanostructures fabricated via the self-assembly of artificial motifs have been a captivating subject because of their structural aesthetics and multiple functionalities. Herein, we report the facile construction of a self-assembled nanohelix (NH) by leveraging an achiral aggregation-induced emission (AIE) luminogen (G) and pillar[5]arene (H), driven by host-guest interactions and metal coordination. Inspired by the "sergeants and soldiers" effect and "majority rule" principle, the host-guest complexation between G and H is employed to fixate the twisted conformation of G for the generation of "contortion sites", which further induced the emergence of helicity as the 1D assemblies are formed via Ag(I) coordination and hexagonally packed into nano-sized fibers. The strategy has proved feasible in both homogeneous and heterogeneous syntheses. Along with the formation of NH, boosted luminescence and enhanced productivity of reactive oxygen species (ROS) are afforded because of the efficient restriction on G, indicating the concurrent regulation of NH's morphology and photophysical properties by supramolecular assembly. In addition, NH also exhibits the capacity for bacteria imaging and photodynamic antibacterial activities against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).
通过人工基序的自组装制备的螺旋纳米结构因其结构美学和多种功能而成为一个引人入胜的研究课题。在此，我们报道了一种通过利用非手性聚集诱导发光（AIE）发光体（G）和柱[5]芳烃（H），在主客体相互作用和金属配位驱动下，简便构建自组装纳米螺旋（NH）的方法。受“军士与士兵”效应和“多数规则”原理的启发，G和H之间的主客体络合被用于固定G的扭曲构象以产生“扭曲位点”，当通过Ag（I）配位形成一维组装体并六方堆积成纳米尺寸的纤维时，这进一步诱导了螺旋性的出现。该策略在均相和非均相合成中均已证明可行。随着NH的形成，由于对G的有效限制，实现了发光增强和活性氧（ROS）生成能力的提高，表明通过超分子组装同时调控了NH的形态和光物理性质。此外，NH还表现出对细菌成像的能力以及对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）的光动力抗菌活性。
