Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Phytother Res. 2023 Nov;37(11):5109-5158. doi: 10.1002/ptr.7974. Epub 2023 Aug 3.
Curcumin, a natural polyphenol, derived from Curcuma longa L. is extensively studied by various researchers across the globe and has established its immense potential in the management of several disorders at clinical level. The underlying mechanism of curcumin involves regulation of various molecular targets, namely, inflammatory cytokines, transcription factor, apoptotic genes, growth factors, oxidative stress biomarkers, and protein kinases. In clinical trials, curcumin as an adjuvant has significantly boost-up the efficacy of many proven drugs in the management of arthritis, neurodegenerative disorder, oral infection, and gastrointestinal disorders. Moreover, clinical studies have suggested curcumin as an appropriate candidate for the prevention and/or management of various cancers via regulation of signaling molecules including NF-kB, cytokines, C-reactive protein, prostaglandin E2, Nrf2, HO-1, ALT, AST, kinases, and blood profiles. This article highlights plethora of clinical trials that have been conducted on curcumin and its derivatives in the management of several ailments. Besides, it provides recent updates to the investigators for conducting future research to fulfill the current gaps to expedite the curcumin utility in clinical subjects bearing different pathological states.
姜黄素是一种天然多酚类物质，来源于姜黄属植物姜黄，受到全球各地研究人员的广泛研究，并已在临床水平上证实其在多种疾病的治疗中有巨大潜力。姜黄素的潜在机制涉及对各种分子靶点的调节，包括炎症细胞因子、转录因子、凋亡基因、生长因子、氧化应激生物标志物和蛋白激酶。在临床试验中，姜黄素作为一种辅助药物，显著提高了许多已被证实的药物在关节炎、神经退行性疾病、口腔感染和胃肠道疾病治疗中的疗效。此外，临床研究表明，姜黄素通过调节 NF-kB、细胞因子、C 反应蛋白、前列腺素 E2、Nrf2、HO-1、ALT、AST、激酶和血液特征等信号分子，是预防和/或治疗各种癌症的合适候选药物。本文重点介绍了大量关于姜黄素及其衍生物在治疗多种疾病方面的临床试验。此外，它为研究人员提供了最新的研究进展，以开展未来的研究，以填补当前的空白，加速姜黄素在不同病理状态的临床患者中的应用。
