Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Curr Neuropharmacol. 2024;23(1):3-19. doi: 10.2174/1570159X22666240731114906.
INTRODUCTION/OBJECTIVE: Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate roles of Notch signaling could pave the way for targeted interventions to mitigate MS progression.
A comprehensive literature review was conducted using databases such as PubMed, Web of Science, and Scopus. Keywords such as "Notch signaling," "neuroglial interactions," and "MS" were used. The selection criteria included relevance to neuroglial interactions, peer-reviewed publications, and studies involving animal models of MS.
This review highlights the diverse functions of Notch signaling in CNS development, including its regulation of neural stem cell differentiation into neurons, astrocytes, and oligodendrocytes. In the context of MS, Notch signaling has emerged as a promising therapeutic target, exhibiting positive impacts on neuroprotection and remyelination. However, its intricate nature within the CNS necessitates precise modulation for therapeutic efficacy.
This study provides a comprehensive overview of the potential therapeutic role of Notch signaling in MS. The findings underscore the significance of Notch modulation for neuroprotection and remyelination, emphasizing the need for precision in therapeutic interventions. Further research is imperative to elucidate the specific underlying mechanisms involved, which will provide a foundation for targeted therapeutic strategies for the management of MS and related neurodegenerative disorders.
简介/目的：多发性硬化症（MS）的特征是自身免疫驱动的神经炎症、轴突变性和脱髓鞘。本研究旨在探索针对中枢神经系统（CNS）中 Notch 信号的治疗潜力，以应对 MS 的发生。深入了解 Notch 信号的复杂作用可能为靶向干预以减轻 MS 进展铺平道路。
使用 PubMed、Web of Science 和 Scopus 等数据库进行全面的文献综述。使用的关键词包括“Notch 信号”、“神经胶质相互作用”和“MS”。选择标准包括与神经胶质相互作用的相关性、同行评审的出版物以及涉及 MS 动物模型的研究。
本综述强调了 Notch 信号在 CNS 发育中的多种功能，包括调节神经干细胞分化为神经元、星形胶质细胞和少突胶质细胞。在 MS 背景下，Notch 信号已成为一个有前途的治疗靶点，对神经保护和髓鞘再生具有积极影响。然而，其在 CNS 中的复杂性质要求进行精确的调节以实现治疗效果。
本研究提供了 Notch 信号在 MS 中的潜在治疗作用的全面概述。研究结果强调了 Notch 调节在神经保护和髓鞘再生中的重要性，突出了治疗干预需要精确性。进一步的研究对于阐明具体的潜在机制至关重要，这将为管理 MS 和相关神经退行性疾病的靶向治疗策略提供基础。
