文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

高压氧对小鼠重度一氧化碳中毒后 Notch 信号通路的影响。

Effects of hyperbaric oxygen on Notch signaling pathway after severe carbon monoxide poisoning in mice.

机构信息

Department of Hyperbaric Medicine, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

Department of Special Operations Medicine, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

出版信息

Med Gas Res. 2023 Jan-Mar;13(1):23-28. doi: 10.4103/2045-9912.344971.

DOI:10.4103/2045-9912.344971
PMID:35946219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9480357/
Abstract

Demyelination of the cerebral white matter is the most common pathological change after carbon monoxide (CO) poisoning. Notch signaling, the mechanism underlying the differentiation of astrocytes and oligodendrocytes, is critical to remyelination of the white matter after brain lesion. The purpose of this work was to determine the effects of hyperbaric oxygen (HBO) on Notch signaling pathway after CO poisoning for the explanation of the protective effects of HBO on CO-poisoning-related cerebral white matter demyelination. The male C57 BL/6 mice with severe CO poisoning were treated by HBO. And HBO therapy shortened the escape latency and improved the body mass after CO poisoning. HBO therapy also significantly suppressed protein and mRNA levels of Notch1 and Hes5 after CO poisoning. Our findings suggested that HBO could suppress the activation of Notch signaling pathway after CO poisoning, which is the mechanism underlying the neuroprotection of HBO on demyelination after severe CO poisoning.

摘要

脑白质脱髓鞘是一氧化碳（CO）中毒后最常见的病理改变。Notch 信号通路是星形胶质细胞和少突胶质细胞分化的机制，对脑损伤后白质的髓鞘再生至关重要。本研究旨在探讨高压氧（HBO）对 CO 中毒后 Notch 信号通路的影响，以解释 HBO 对 CO 中毒相关脑白质脱髓鞘的保护作用。采用 HBO 治疗雄性 C57BL/6 小鼠重度 CO 中毒。HBO 治疗可缩短 CO 中毒后的逃避潜伏期，改善体重。HBO 治疗还显著抑制了 CO 中毒后 Notch1 和 Hes5 的蛋白和 mRNA 水平。我们的研究结果表明，HBO 可抑制 CO 中毒后 Notch 信号通路的激活，这是 HBO 对重度 CO 中毒后脱髓鞘神经保护作用的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/09ba8607150b/MGR-13-23-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/67e5cc493b9a/MGR-13-23-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/003c1e419b9f/MGR-13-23-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/d85f4c96fe48/MGR-13-23-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/ce232992a5ff/MGR-13-23-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/09ba8607150b/MGR-13-23-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/67e5cc493b9a/MGR-13-23-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/003c1e419b9f/MGR-13-23-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/d85f4c96fe48/MGR-13-23-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/ce232992a5ff/MGR-13-23-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/09ba8607150b/MGR-13-23-g005.jpg

相似文献

[1]
Effects of hyperbaric oxygen on Notch signaling pathway after severe carbon monoxide poisoning in mice.

Med Gas Res. 2023

[2]
[The mechanism of hyperbaric oxygen regulating HMGB1 in the prevention and treatment of encephalopathy after acute CO poisoning].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2020-9-20

[3]
Hyperbaric oxygen does not prevent neurologic sequelae after carbon monoxide poisoning.

Acad Emerg Med. 2002-1

[4]
Neurocognitive sequelae after carbon monoxide poisoning and hyperbaric oxygen therapy.

Med Gas Res. 2020

[5]
Single Versus Multiple Hyperbaric Sessions for Carbon Monoxide Poisoning in a Murine Model.

J Med Toxicol. 2016-12

[6]
Effects of hyperbaric oxygen on hippocampal neuronal apoptosis in rats with acute carbon monoxide poisoning.

Undersea Hyperb Med. 2017

[7]
Outcome of patients experiencing cardiac arrest with carbon monoxide poisoning treated with hyperbaric oxygen.

Ann Emerg Med. 2001-7

[8]
Hyperbaric oxygen for carbon monoxide poisoning.

Cochrane Database Syst Rev. 2000

[9]
Optimal sessions of hyperbaric oxygen therapy in patients with carbon monoxide poisoning: A prospective observational study.

Am J Emerg Med. 2021-6

[10]
Hyperbaric oxygen therapy in carbon monoxide poisoning in pregnancy: Maternal and fetal outcome.

Am J Emerg Med. 2021-5

引用本文的文献

[1]
Oxygen therapy in the intensive care unit.

Med Gas Res. 2025-12-1

[2]
Neuroprotective Effect of Rosuvastatin Calcium Combined with Hyperbaric Oxygen Mediated p38MAPK Pathway in Rats with Leukoaraiosis.

Cell Biochem Biophys. 2025-3-22

[3]
Notch Signaling in Central Nervous System: From Cellular Development to Multiple Sclerosis Disease.

Curr Neuropharmacol. 2024

[4]
Glycerophosphoinositol modulates FGA and NOTCH3 in exercise-induced muscle adaptation and colon cancer progression.

Front Pharmacol. 2024-7-26

[5]
Deacetylase SIRT2 Inhibition Promotes Microglial M2 Polarization Through Axl/PI3K/AKT to Alleviate White Matter Injury After Subarachnoid Hemorrhage.

Transl Stroke Res. 2024-8-5

[6]
The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss.

Med Gas Res. 2024-12-1

本文引用的文献

[1]
WITHDRAWN: MiR-216b-5p attenuates chronic constriction injury-induced neuropathic pain in female rats by targeting MAL2 and inactivating Wnt/β-catenin signaling pathway.

Neurochem Int. 2020-11-28

[2]
Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning.

Undersea Hyperb Med. 2020

[3]
Selective Susceptibility of Oligodendrocytes to Carbon Monoxide Poisoning: Implication for Delayed Neurologic Sequelae (DNS).

Front Psychiatry. 2020-8-13

[4]
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

PLoS Biol. 2020-7-14

[5]
Carbon monoxide poisoning.

Undersea Hyperb Med. 2020

[6]
Phosphorylation and Proteolytic Cleavage of Notch in Canonical and Noncanonical Notch Signaling.

Adv Exp Med Biol. 2020

[7]
Overview of Basic Mechanisms of Notch Signaling in Development and Disease.

Adv Exp Med Biol. 2020

[8]
A Snapshot of the Molecular Biology of Notch Signaling: Challenges and Promises.

Adv Exp Med Biol. 2020

[9]
Notch Signaling and Embryonic Development: An Ancient Friend, Revisited.

Adv Exp Med Biol. 2020

[10]
Oligodendrocyte dysfunction and regeneration failure: A novel hypothesis of delayed encephalopathy after carbon monoxide poisoning.

Med Hypotheses. 2020-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索