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高压氧对小鼠重度一氧化碳中毒后 Notch 信号通路的影响。

Effects of hyperbaric oxygen on Notch signaling pathway after severe carbon monoxide poisoning in mice.

机构信息

Department of Hyperbaric Medicine, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

Department of Special Operations Medicine, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

出版信息

Med Gas Res. 2023 Jan-Mar;13(1):23-28. doi: 10.4103/2045-9912.344971.

DOI:10.4103/2045-9912.344971
PMID:35946219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9480357/
Abstract

Demyelination of the cerebral white matter is the most common pathological change after carbon monoxide (CO) poisoning. Notch signaling, the mechanism underlying the differentiation of astrocytes and oligodendrocytes, is critical to remyelination of the white matter after brain lesion. The purpose of this work was to determine the effects of hyperbaric oxygen (HBO) on Notch signaling pathway after CO poisoning for the explanation of the protective effects of HBO on CO-poisoning-related cerebral white matter demyelination. The male C57 BL/6 mice with severe CO poisoning were treated by HBO. And HBO therapy shortened the escape latency and improved the body mass after CO poisoning. HBO therapy also significantly suppressed protein and mRNA levels of Notch1 and Hes5 after CO poisoning. Our findings suggested that HBO could suppress the activation of Notch signaling pathway after CO poisoning, which is the mechanism underlying the neuroprotection of HBO on demyelination after severe CO poisoning.

摘要

脑白质脱髓鞘是一氧化碳（CO）中毒后最常见的病理改变。Notch 信号通路是星形胶质细胞和少突胶质细胞分化的机制，对脑损伤后白质的髓鞘再生至关重要。本研究旨在探讨高压氧（HBO）对 CO 中毒后 Notch 信号通路的影响，以解释 HBO 对 CO 中毒相关脑白质脱髓鞘的保护作用。采用 HBO 治疗雄性 C57BL/6 小鼠重度 CO 中毒。HBO 治疗可缩短 CO 中毒后的逃避潜伏期，改善体重。HBO 治疗还显著抑制了 CO 中毒后 Notch1 和 Hes5 的蛋白和 mRNA 水平。我们的研究结果表明，HBO 可抑制 CO 中毒后 Notch 信号通路的激活，这是 HBO 对重度 CO 中毒后脱髓鞘神经保护作用的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/09ba8607150b/MGR-13-23-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/67e5cc493b9a/MGR-13-23-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/003c1e419b9f/MGR-13-23-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/d85f4c96fe48/MGR-13-23-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/ce232992a5ff/MGR-13-23-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/09ba8607150b/MGR-13-23-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/67e5cc493b9a/MGR-13-23-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/003c1e419b9f/MGR-13-23-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/d85f4c96fe48/MGR-13-23-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/ce232992a5ff/MGR-13-23-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a05/9480357/09ba8607150b/MGR-13-23-g005.jpg

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