[Effect of mutations damaging cyclic adenosine-3',5'-monophosphate receptor protein on the expression of catabolic operons in Escherichia coli delta ptsH K12].

Effectivity of expression of catabolite operons is repressed in bacteria with altered cytoplasmic components of the sugar, transport system (pts mutants). Mutation crp* changing the ability of the cyclic adenosine-3',5'-monophosphate receptor protein to activate transcription leads to suppression of the pts mediated disturbance of the enzyme inducible synthesis. This suppression manifests in ability of double delta ptsH crp* mutants to utilize different substrates and in restoration of the rate of beta-galactosidase synthesis and L-tryptophanase synthesis up to the levels in wild type bacteria.