Rana Srishti, Thakur Neha, Thakur Ruhi
School of Biological and Environmental Sciences, Shoolini University, Solan, India, 173229.
Biol Trace Elem Res. 2024 Aug 20. doi: 10.1007/s12011-024-04344-9.
This review explores the diverse effects of fluoride on pancreatic function, encompassing both in vitro and in vivo studies. Fluoride exposure induces notable alterations at the cellular and molecular levels, affecting pancreatic morphology, histology, and enzymatic activity. In vitro studies demonstrate significant inhibition of pancreatic α-amylase activity and apoptosis in pancreatic beta cells. In vivo investigations reveal structural abnormalities in pancreatic cells, including mitochondrial damage, vacuolation, and nuclear damage. Moreover, fluoride exposure disrupts antioxidant enzyme activity, exacerbating oxidative stress and lipid peroxidation. Changes in digestive enzyme activity, such as the inhibition of pancreatic lipase and α-amylase, further contribute to pancreatic dysfunction. Additionally, alterations in hormone secretion, notably insulin levels and disturbed glucose homeostasis, highlight the complex effects of fluoride on the pancreatic endocrine system. These findings underscore fluoride-induced pancreatic toxicity and highlight the need for a comprehensive understanding and mitigation strategies to safeguard pancreatic health.
本综述探讨了氟化物对胰腺功能的多种影响，涵盖了体外和体内研究。氟化物暴露在细胞和分子水平上引起显著变化，影响胰腺形态、组织学和酶活性。体外研究表明，胰腺α-淀粉酶活性受到显著抑制，胰腺β细胞发生凋亡。体内研究揭示了胰腺细胞的结构异常，包括线粒体损伤、空泡化和核损伤。此外，氟化物暴露会破坏抗氧化酶活性，加剧氧化应激和脂质过氧化。消化酶活性的变化，如胰腺脂肪酶和α-淀粉酶的抑制，进一步导致胰腺功能障碍。此外，激素分泌的改变，尤其是胰岛素水平和葡萄糖稳态的紊乱，突出了氟化物对胰腺内分泌系统的复杂影响。这些发现强调了氟化物诱导的胰腺毒性，并突出了全面理解和采取缓解策略以保护胰腺健康的必要性。
