Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Curr Diab Rep. 2024 Oct;24(10):227-235. doi: 10.1007/s11892-024-01550-6. Epub 2024 Aug 20.
Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight.
Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies such as time restricted eating, following the 24 h movement guidelines, or reducing sedentary behavior during pregnancy can be successful approaches benefiting the maternal metabolic milieu and minimize the risk of adverse pregnancy outcomes. Personalized tools such as continuous glucose monitors or community-based approaches play an important role in pre-conception health and should be extrapolated to pregnancy interventions to directly benefit the metabolic milieu optimizing health outcomes for both parent and child.
肥胖女性怀孕会增加母婴健康不良结局的风险。因此，研究干预措施主要集中在限制怀孕期间的体重过度增加，尤其是肥胖女性。然而，尽管许多生活方式干预措施成功地减少了 GWG，但很少有干预措施能影响妊娠结局。在这里，我们回顾了针对代谢环境的工作，而不仅仅是关注体重。
在非孕妇人群中的研究表明，专门针对血糖、甘油三酯和瘦素水平或炎症标志物进行治疗，可以改善代谢环境和整体健康状况。我们假设，包括限时进食、遵循 24 小时运动指南或减少怀孕期间久坐行为等策略的精准干预措施，可以成功改善母体代谢环境，最大限度地降低不良妊娠结局的风险。连续血糖监测仪等个性化工具或社区为基础的方法在孕前健康中发挥着重要作用，应该推广到妊娠干预措施中，直接改善代谢环境，优化母婴健康结局。
