Consultant Neurologist, Department of Neurology, St Joseph Hospital, Kollam, Kerala, India, Corresponding Author.
Consultant Neurologist, Department of Neurology, Welcare Hospital, Kochi, Kerala, India.
J Assoc Physicians India. 2024 Aug;72(8):89. doi: 10.59556/japi.72.0579.
Pantoprazole is an extensively used proton pump inhibitor (PPI) for acid peptic disease. PPI rarely cause hypomagnesemia. Hypomagnesemia is commonly associated with hypokalemia and hypocalcemia. Severe hypomagnesemia and hypocalcemia can cause seizures. Here, we report a patient on long-term pantoprazole who presented with generalized tonic-clonic seizures and had severe hypomagnesemia, hypocalcemia, hypokalemia, and secondary hyperparathyroidism. When patients on long-term PPI present with seizures, hypomagnesemia/hypocalcemia has to be excluded.
泮托拉唑是一种广泛用于治疗酸相关消化性疾病的质子泵抑制剂（PPI）。PPI 很少引起低镁血症。低镁血症通常与低钾血症和低钙血症有关。严重的低镁血症和低钙血症可引起癫痫发作。在这里，我们报告了一例长期使用泮托拉唑的患者，其出现全身强直阵挛性发作，且伴有严重的低镁血症、低钙血症、低钾血症和继发性甲状旁腺功能亢进症。当长期使用 PPI 的患者出现癫痫发作时，必须排除低镁血症/低钙血症。
