Junior Resident, Department of General Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India, Corresponding Author.
Associate Professor, Department of General Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
J Assoc Physicians India. 2024 Aug;72(8):107-108. doi: 10.59556/japi.72.0586.
We present a case of a 56-year-old female with rheumatoid arthritis (RA) who has been on methotrexate for 9 years and has been complaining of high-grade fever for the past 1 month with no localizing signs and symptoms. She was thoroughly evaluated before being labeled as pyrexia of unknown origin. Histoplasmosis was suspected after bone marrow aspiration smear examination. The presence of histoplasma antigen in the urine confirmed our diagnosis. Fever responded after 2 weeks of liposomal amphotericin B and patient discharged in stable condition on tablet itraconazole.
我们报告一例 56 岁女性类风湿关节炎（RA）患者，她已接受甲氨蝶呤治疗 9 年，过去 1 个月一直有高热，无定位体征和症状。在被标记为原因不明发热之前，她进行了全面评估。骨髓抽吸涂片检查后怀疑为组织胞浆菌病。尿中组织胞浆菌抗原的存在证实了我们的诊断。在接受两性霉素 B 脂质体治疗 2 周后，发热得到缓解，患者出院时情况稳定，继续服用伊曲康唑片剂。
