Human mononuclear phagocytic cell interaction with some Paramyxoviridae.

In consideration of the peculiar relationship between Paramyxoviridae and immunocompetent system, we studied interactions of measles virus, Newcastle-disease virus and respiratory syncytial virus with human monocytes and macrophages differentiated "in vitro". Mononuclear cells were challenged with three different Paramyxovirus at different multiplicities of infection. Infected cells were then checked for expression of specific viral antigens by immunofluorescent test (FA). Moreover, we have evaluated the intrinsic antiviral activity and single cycle growth curves.