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Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme.

作者信息

Brent T P

出版信息

Pharmacol Ther. 1985;31(1-2):121-40. doi: 10.1016/0163-7258(85)90040-3.

DOI:10.1016/0163-7258(85)90040-3
PMID:3916338
Abstract
摘要

相似文献

1
Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme.从人白血病细胞中分离和纯化O6-烷基鸟嘌呤-DNA烷基转移酶。纯化酶对氯乙基亚硝脲诱导的交联的预防作用。
Pharmacol Ther. 1985;31(1-2):121-40. doi: 10.1016/0163-7258(85)90040-3.
2
Formation of DNA interstrand cross-links by the novel chloroethylating agent 2-chloroethyl(methylsulfonyl)methanesulfonate: suppression by O6-alkylguanine-DNA alkyltransferase purified from human leukemic lymphoblasts.新型氯乙基化剂2-氯乙基（甲基磺酰基）甲磺酸盐诱导DNA链间交联的形成：从人白血病淋巴母细胞中纯化的O6-烷基鸟嘌呤-DNA烷基转移酶对其的抑制作用
Cancer Res. 1987 Jul 1;47(13):3384-7.
3
Characterization of a novel reaction by human O6-alkylguanine-DNA alkyltransferase with 1,3-bis(2-chloroethyl)-1-nitrosourea-treated DNA.
Cancer Res. 1987 Dec 1;47(23):6185-8.
4
Evidence that O6-alkylguanine-DNA alkyltransferase becomes covalently bound to DNA containing 1,3-bis(2-chloroethyl)-1-nitrosourea-induced precursors of interstrand cross-links.
Biochem Biophys Res Commun. 1987 Jan 30;142(2):341-7. doi: 10.1016/0006-291x(87)90279-8.
5
Affinity purification and characterization of human O6-alkylguanine-DNA alkyltransferase complexed with BCNU-treated, synthetic oligonucleotide.与经卡莫司汀处理的合成寡核苷酸复合的人O6-烷基鸟嘌呤-DNA烷基转移酶的亲和纯化及特性鉴定
Nucleic Acids Res. 1989 Aug 25;17(16):6581-90. doi: 10.1093/nar/17.16.6581.
6
Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.O6-甲基鸟嘌呤对氯乙基亚硝基脲和2-氯乙基（甲基磺酰基）甲磺酸酯形成DNA链间交联的影响。
Cancer Res. 1988 Jul 1;48(13):3603-6.
7
Regeneration of O6-alkylguanine-DNA alkyltransferase in human lymphocytes after nitrosourea exposure.亚硝基脲暴露后人淋巴细胞中O6-烷基鸟嘌呤-DNA烷基转移酶的再生
Cancer Res. 1988 Sep 15;48(18):5368-73.
8
[The age-related dynamics of the activity of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase in different organs of rats].[大鼠不同器官中DNA修复酶O6-烷基鸟嘌呤-DNA烷基转移酶活性的年龄相关动态变化]
Vopr Onkol. 1991;37(2):197-203.
9
Prevention of 1-(3-deoxycytidyl),2-(1-deoxyguanosinyl)ethane cross-link formation in DNA by rat liver O6-alkylguanine-DNA alkyltransferase.大鼠肝脏O6-烷基鸟嘌呤-DNA烷基转移酶对DNA中1-(3-脱氧胞苷基),2-(1-脱氧鸟苷基)乙烷交联形成的预防作用
Cancer Res. 1986 Jul;46(7):3353-7.
10
Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.用O6-烷基鸟嘌呤处理的HeLa细胞中O6-烷基鸟嘌呤-DNA烷基转移酶活性的降低
Cancer Res. 1985 Dec;45(12 Pt 1):6413-7.

引用本文的文献

1
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.缺氧条件下选择性 O(6)-烷基鸟嘌呤-DNA 烷基转移酶耗竭的策略。
Chem Biol Drug Des. 2012 Aug;80(2):279-90. doi: 10.1111/j.1747-0285.2012.01401.x. Epub 2012 May 23.
2
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.O6-烷基鸟嘌呤-DNA烷基转移酶碱基修复中的DNA结合、核苷酸翻转及螺旋-转角-螺旋基序及其对癌症化疗的意义。
DNA Repair (Amst). 2007 Aug 1;6(8):1100-15. doi: 10.1016/j.dnarep.2007.03.011. Epub 2007 May 7.
3
Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells.
O6-甲基鸟嘌呤-DNA甲基转移酶增强子结合蛋白在DNA修复缺陷型人类细胞中的细胞质隔离
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4348-53. doi: 10.1073/pnas.94.9.4348.
4
Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.O6-苄基鸟嘌呤对前列腺癌邓宁R3327G模型中1,3-双（2-氯乙基）-1-亚硝基脲反应的影响
Cancer Chemother Pharmacol. 1993;32(3):221-5. doi: 10.1007/BF00685839.
5
The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.O6-苄基鸟嘌呤和缺氧对亚硝基脲耐药的SF-763细胞中1,3-双（2-氯乙基）-1-亚硝基脲细胞毒性的影响。
Cancer Chemother Pharmacol. 1993;32(6):477-81. doi: 10.1007/BF00685893.
6
Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.谷胱甘肽、细胞增殖与1,3 - 双（2 - 氯乙基）- 1 - 亚硝基脲在K562白血病中的作用
J Clin Invest. 1993 Dec;92(6):2761-7. doi: 10.1172/JCI116894.
7
Interrelationship between O6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosoureas in several glioma cell lines.几种胶质瘤细胞系中O6-烷基鸟嘌呤-DNA烷基转移酶活性与对氯乙基亚硝脲敏感性之间的相互关系。
J Neurooncol. 1993 Jul;17(1):1-8. doi: 10.1007/BF01054267.
8
Formation of covalent complexes between human O6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides.人O6-烷基鸟嘌呤-DNA烷基转移酶与卡氮芥处理的特定长度合成寡脱氧核苷酸之间共价复合物的形成。
Nucleic Acids Res. 1988 Jul 25;16(14B):6779-88. doi: 10.1093/nar/16.14.6779.
9
Repair of O-alkylpyrimidines in mammalian cells: a present consensus.哺乳动物细胞中O-烷基嘧啶的修复：当前共识
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1759-62. doi: 10.1073/pnas.85.6.1759.
10
Affinity purification and characterization of human O6-alkylguanine-DNA alkyltransferase complexed with BCNU-treated, synthetic oligonucleotide.与经卡莫司汀处理的合成寡核苷酸复合的人O6-烷基鸟嘌呤-DNA烷基转移酶的亲和纯化及特性鉴定
Nucleic Acids Res. 1989 Aug 25;17(16):6581-90. doi: 10.1093/nar/17.16.6581.