Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Department of Veterinary Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
PLoS One. 2024 Aug 20;19(8):e0308984. doi: 10.1371/journal.pone.0308984. eCollection 2024.
Canine hip dysplasia (CHD) is a common orthopedic condition, influenced by both genetic and environmental factors. While current breeding programs often rely on ventrodorsal hip-extended (VDHE) radiographs, it is known they fail to accurately assess hip joint laxity. Therefore additional laxity-oriented diagnostic techniques have been developed. This study aims to evaluate the effectiveness of the Vezzoni modified Bädertscher distension device (VMBDD) technique, which quantifies hip joint laxity with the laxity index (LI), as a screening tool in two breeding programs. Data from a Belgian population of assistance dogs (population A) and a French population of guide dogs (population B) were analyzed. The heritability estimates of the LI, estimated using Bayesian statistical methods, were high in both populations (0.83 in population A and 0.82 in population B). Improved screening of parents by combining the VMBDD technique with the VDHE, significantly decreased LI and the prevalence of CHD in their offspring. In population A, when two parents were screened with the VMBDD compared to one, there was an average LI decrease of 0.03 (P<0.05). In population B, when one or both parents were screened with the VMBDD compared to none, the average LI decrease was 0.04 (P< 0.05) and 0.05 (P<0.01), respectively. In population A, screening both parents with the VMBDD in addition to the VDHE, resulted in 82.7% (P< 0.05) lower odds of CHD compared to screening only one parent. In population B, screening one parent led to 72.3% (P<0.05) lower odds of CHD compared to none of the parents being screened. In population B, when both parents were screened with the VMBDD, not a single case of CHD was observed in the puppies. In conclusion, based on these results, the VMBDD technique has the potential to drastically reduce CHD prevalence and is as such an excellent tool for breeding programs.
犬髋关节发育不良（CHD）是一种常见的骨科疾病，受遗传和环境因素的影响。虽然目前的繁殖计划通常依赖于背腹位髋关节伸展（VDHE）射线照相，但已知它们无法准确评估髋关节的松弛度。因此，已经开发了其他针对松弛度的诊断技术。本研究旨在评估 Vezzoni 改良的 Bädertscher 扩张装置（VMBDD）技术的有效性，该技术通过松弛度指数（LI）量化髋关节松弛度，作为两个繁殖计划中的筛选工具。分析了来自比利时辅助犬种群（种群 A）和法国导盲犬种群（种群 B）的数据。使用贝叶斯统计方法估计的 LI 的遗传力估计在两个种群中均较高（种群 A 为 0.83，种群 B 为 0.82）。通过将 VMBDD 技术与 VDHE 相结合，对父母进行更好的筛选，显著降低了其后代的 LI 和 CHD 的患病率。在种群 A 中，当与仅对一个父母进行筛选相比，当对两个父母进行 VMBDD 筛选时，LI 平均降低了 0.03（P<0.05）。在种群 B 中，当与没有父母筛选相比，当一个或两个父母用 VMBDD 筛选时，LI 的平均降低分别为 0.04（P<0.05）和 0.05（P<0.01）。在种群 A 中，与仅对一个父母进行 VDHE 筛选相比，当除了 VDHE 之外，还对两个父母进行 VMBDD 筛选时，CHD 的患病几率降低了 82.7%（P<0.05）。在种群 B 中，与没有父母筛选相比，当对一个父母进行筛选时，CHD 的患病几率降低了 72.3%（P<0.05）。在种群 B 中，当两个父母都用 VMBDD 筛选时，幼犬中没有一例 CHD 病例。总之，基于这些结果，VMBDD 技术有可能大幅降低 CHD 的患病率，因此是繁殖计划的极好工具。
