Thyroid Gland Breast Surgery, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
Department of Hemodialysis, Huangshi Central Hospital, Huangshi, China.
J Cell Mol Med. 2024 Aug;28(16):e18587. doi: 10.1111/jcmm.18587.
Thyroid cancer (TC) is a prevalent endocrine malignancy, with a significant increase in incidence worldwide. Ferroptosis is a novel form of programmed cell death, primarily caused by iron overload and reactive oxygen species (ROS)-dependent accumulation of lipid peroxides. The main manifestations of cellular ferroptosis are rupture of the outer membrane, crumpling of the mitochondria and shrinkage or disappearance of the mitochondrial cristae, thus leading to cell death. Ferroptosis is an important phenomenon in tumour progression, with crosstalk with tumour-associated signalling pathways profoundly affecting tumour progression, immune effects and treatment outcomes. The functions and mechanisms of ferroptosis in TC have also attracted increasing attention, mainly in terms of influencing tumour proliferation, invasion, migration, immune response, therapeutic susceptibility and genetic susceptibility. However, at present, the tumour biology of the morphological, biological and mechanism pathways of ferroptosis is much less deep in TC than in other malignancies. Hence, in this review, we highlighted the emerging role of ferroptosis in TC progression, including the novel mechanisms and potential opportunities for diagnosis and treatment, as well as discussed the limitations and prospects. Ferroptosis-based diagnostic and therapeutic strategies can potentially provide complementary management of TCs.
甲状腺癌（TC）是一种常见的内分泌恶性肿瘤，全球发病率显著增加。铁死亡是一种新的细胞程序性死亡形式，主要由铁过载和活性氧（ROS）依赖性脂质过氧化物积累引起。细胞铁死亡的主要表现为细胞膜外膜破裂、线粒体皱缩和线粒体嵴缩小或消失，从而导致细胞死亡。铁死亡是肿瘤进展中的一个重要现象，与肿瘤相关信号通路的相互作用深刻影响肿瘤的进展、免疫效应和治疗效果。铁死亡在 TC 中的功能和机制也引起了越来越多的关注，主要涉及影响肿瘤增殖、侵袭、迁移、免疫反应、治疗敏感性和遗传易感性。然而，目前，铁死亡在 TC 中的形态、生物学和机制途径的肿瘤生物学研究远不如其他恶性肿瘤深入。因此，在这篇综述中，我们强调了铁死亡在 TC 进展中的新作用，包括新的机制和诊断与治疗的潜在机会，并讨论了其局限性和前景。基于铁死亡的诊断和治疗策略可能为 TC 的管理提供补充。
