The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
Department of Surgical Oncology, Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China.
Biomed Pharmacother. 2024 Aug;177:116971. doi: 10.1016/j.biopha.2024.116971. Epub 2024 Jun 19.
Thyroid cancer is a prevalent endocrine malignancy whose global incidence has risen over the past several decades. Ferroptosis, a regulated form of cell death distinguished by the excessive buildup of iron-dependent lipid peroxidates, stands out from other programmed cell death pathways in terms of morphological and molecular characteristics. Increasing evidence suggests a close association between thyroid cancer and ferroptosis, that is, inducing ferroptosis effectively suppresses the proliferation of thyroid cancer cells and impede tumor advancement. Therefore, ferroptosis represents a promising therapeutic target for the clinical management of thyroid cancer in clinical settings. Alterations in ferroptosis-related genes hold potential for prognostic prediction in thyroid cancer. This review summarizes current studies on the role of ferroptosis in thyroid cancer, elucidating its mechanisms, therapeutic targets, and predictive biomarkers. The findings underscore the significance of ferroptosis in thyroid cancer and offer valuable insights into the development of innovative treatment strategies and accurate predictors for the thyroid cancer.
甲状腺癌是一种常见的内分泌恶性肿瘤，在过去几十年中其全球发病率一直在上升。铁死亡是一种受调控的细胞死亡形式，其特征是铁依赖性脂质过氧化物的过度积累，在形态和分子特征上有别于其他程序性细胞死亡途径。越来越多的证据表明，甲状腺癌与铁死亡之间存在密切关联，即有效诱导铁死亡可抑制甲状腺癌细胞的增殖并阻碍肿瘤进展。因此，铁死亡代表了甲状腺癌临床治疗中一个很有前景的治疗靶点。铁死亡相关基因的改变可能对甲状腺癌的预后预测具有潜在价值。本综述总结了铁死亡在甲状腺癌中的作用的相关研究，阐明了其机制、治疗靶点和预测生物标志物。这些研究结果强调了铁死亡在甲状腺癌中的重要性，并为开发创新的治疗策略和准确预测甲状腺癌提供了有价值的见解。
