School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, 100048, P. R. China.
Mycotoxin Res. 2024 Nov;40(4):483-494. doi: 10.1007/s12550-024-00553-2. Epub 2024 Aug 21.
Mycotoxins are secondary metabolites produced by fungi with harmful effects such as carcinogenicity, teratogenicity, nephrotoxicity, and hepatotoxicity. They cause widespread contamination of plant products such as crops, food, and feed, posing serious threats to the life and health of human beings and animals. It has been found that many traditionally synthesized and natural compounds are capable of inhibiting the growth of fungi and their secondary metabolite production. Natural compounds have attracted much attention due to their safety, environmental, and health friendly features. In this paper, compounds of plant origin with inhibitory effects on ochratoxins, aflatoxins, Fusarium toxins, and Alternaria toxins, including cinnamaldehyde, citral, magnolol, eugenol, pterostilbene, curcumin, and phenolic acid, are reviewed, and the inhibitory mechanisms of different compounds on the toxin production of fungi are also elucidated, with the aim of providing application references to reduce the contamination of fungal toxins, thus safeguarding the health of human beings and animals.
真菌毒素是真菌产生的次生代谢物，具有致癌性、致畸性、肾毒性和肝毒性等有害影响。它们会导致农作物、食品和饲料等植物产品的广泛污染，对人类和动物的生命和健康构成严重威胁。已经发现许多传统合成和天然化合物能够抑制真菌的生长及其次生代谢产物的产生。由于天然化合物具有安全性、环境友好和对健康无害的特点，因此引起了广泛关注。本文综述了具有抑制赭曲霉毒素、黄曲霉毒素、镰刀菌毒素和交链孢毒素产生的植物源化合物，包括肉桂醛、柠檬醛、厚朴酚、丁香酚、紫檀芪、姜黄素和酚酸，并阐明了不同化合物对真菌毒素产生的抑制机制，以期为减少真菌毒素污染提供应用参考，从而保障人类和动物的健康。
