Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 69 Dongxia North Road, Shantou, 515000, China.
Shantou University Medical College, Shantou, China.
Lipids Health Dis. 2024 Aug 20;23(1):257. doi: 10.1186/s12944-024-02254-2.
A high triglyceride-glucose index (TyG) is associated with a higher risk of incident heart failure. However, the effects of longitudinal patterns of TyG index on the risk of heart failure remain to be characterized. Therefore, in the present study, we aimed to characterize the relationship between the trajectory of TyG index and the risk of heart failure.
We performed a prospective study of 56,149 participants in the Kailuan study who attended three consecutive surveys in 2006-2007, 2008-2009, and 2010-2011 and had no history of heart failure or cancer before the third wave survey (2010-2011). The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2], and we used latent mixture modeling to characterize the trajectory of the TyG index over the period 2006-2010. Additionally, Cox proportional risk models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for incident heart failure for the various TyG index trajectory groups.
From 2006 to 2010, four different TyG trajectories were identified: low-stable (n = 13,554; range, 7.98-8.07), moderate low-stable (n = 29,435; range, 8.60-8.65), moderate high-stable (n = 11,262; range, 9.31-9.30), and elevated-stable (n = 1,898; range, 10.04-10.25). A total of 1,312 new heart failure events occurred during a median follow-up period of 10.04 years. After adjustment for potential confounders, the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident heart failure for the elevated-stable, moderate high-stable, and moderate low-stable groups were 1.55 (1.15, 2.08), 1.32 (1.08, 1.60), and 1.17 (0.99, 1.37), respectively, compared to the low-stable group.
Higher TyG index trajectories were associated with a higher risk of heart failure. This suggests that monitoring TyG index trajectory may help identify individuals at high risk for heart failure and highlights the importance of early control of blood glucose and lipids for the prevention of heart failure.
甘油三酯-葡萄糖指数（TyG）升高与心力衰竭事件风险增加相关。然而，TyG 指数的纵向变化模式与心力衰竭风险之间的关系仍有待明确。因此，本研究旨在描述 TyG 指数轨迹与心力衰竭风险之间的关系。
我们对参加了 2006-2007 年、2008-2009 年和 2010-2011 年三次连续调查且在第三次调查（2010-2011 年）前无心力衰竭或癌症病史的 56149 例开滦研究参与者进行了前瞻性研究。TyG 指数计算方法为 ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]，我们采用潜在混合模型来描述 2006-2010 年 TyG 指数的轨迹。此外，还采用 Cox 比例风险模型计算了不同 TyG 指数轨迹组心力衰竭事件的风险比（HR）和 95%置信区间（CI）。
在 2006 年至 2010 年期间，共确定了 4 种不同的 TyG 轨迹：低稳定组（n=13554，范围为 7.98-8.07）、中低稳定组（n=29435，范围为 8.60-8.65）、中高稳定组（n=11262，范围为 9.31-9.30）和高稳定组（n=1898，范围为 10.04-10.25）。在中位随访 10.04 年期间共发生 1312 例新发心力衰竭事件。在调整潜在混杂因素后，与低稳定组相比，高稳定组、中高稳定组和中低稳定组发生心力衰竭事件的风险比（HR）和 95%置信区间（CI）分别为 1.55（1.15，2.08）、1.32（1.08，1.60）和 1.17（0.99，1.37）。
较高的 TyG 指数轨迹与心力衰竭风险增加相关。这表明监测 TyG 指数轨迹可能有助于识别心力衰竭风险较高的个体，并强调了早期控制血糖和血脂对预防心力衰竭的重要性。
