School of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd, Tehran, 1417613151, Iran.
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Lipids Health Dis. 2024 Jan 8;23(1):4. doi: 10.1186/s12944-024-02005-3.
Obstructive sleep apnea (OSA) has a bidirectional association with metabolic syndrome, and insulin resistance (IR). The triglyceride-glucose (TyG) index could be a simply calculated marker of IR in OSA. However, its clinical application appears still limited. Hence, this systematic review and meta-analysis aimed to respond to this question by analyzing all the existing studies showing an association between OSA and the TyG index.
Four online databases, including PubMed, Scopus, the Web of Science, and Embase were searched for studies evaluating the TyG index in OSA. After screening and data extraction, a random-effect meta-analysis was performed to compare the TyG index in OSA patients vs. healthy controls by calculating standardized mean difference (SMD) and 95% confidence interval (CI) and pooling the area under the curves (AUCs) for diagnosis of OSA based on this index.
Ten studies involving 16,726 individuals were included in the current systematic review. Meta-analysis indicated that there was a significantly higher TyG index in patients with OSA, compared with the healthy controls (SMD 0.856, 95% CI 0.579 to 1.132, P < 0.001). Also, TyG had a diagnostic ability for OSA representing a pooled AUC of 0.681 (95% CI 0.627 to 0.735). However, based on the two studies' findings, no difference between different severities of OSA was observed. Finally, our data showed that the TyG index is a good potential predictor of adverse outcomes in these patients.
Our study revealed that the TyG index is an easy-to-measure marker of IR for assessing OSA, both in diagnosis and prognosis. Our study supports its implementation in routine practice to help clinicians in decision-making and patient stratification.
阻塞性睡眠呼吸暂停（OSA）与代谢综合征和胰岛素抵抗（IR）呈双向关联。三酰甘油-葡萄糖（TyG）指数可作为 OSA 中 IR 的简单计算标志物。然而，其临床应用似乎仍然有限。因此，本系统评价和荟萃分析旨在通过分析所有显示 OSA 与 TyG 指数之间存在关联的现有研究来回答这个问题。
在 PubMed、Scopus、Web of Science 和 Embase 这四个在线数据库中搜索评估 OSA 中 TyG 指数的研究。经过筛选和数据提取，采用随机效应荟萃分析比较了 OSA 患者与健康对照组的 TyG 指数，计算标准化均数差（SMD）和 95%置信区间（CI），并汇总基于该指数诊断 OSA 的曲线下面积（AUC）。
本系统评价纳入了 10 项研究，共涉及 16726 人。荟萃分析表明，与健康对照组相比，OSA 患者的 TyG 指数显著更高（SMD 0.856，95%CI 0.579 至 1.132，P<0.001）。此外，TyG 对 OSA 具有诊断能力，汇总 AUC 为 0.681（95%CI 0.627 至 0.735）。然而，基于两项研究的结果，不同严重程度的 OSA 之间没有差异。最后，我们的数据表明，TyG 指数是这些患者不良结局的良好潜在预测指标。
我们的研究表明，TyG 指数是一种易于测量的 IR 标志物，可用于评估 OSA，无论是在诊断还是预后方面。我们的研究支持将其纳入常规实践，以帮助临床医生做出决策和对患者进行分层。
