Liu Jinya, Chen Yuanyuan, Peng Cheng
Department of Burn and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Diabetol Metab Syndr. 2024 Aug 20;16(1):202. doi: 10.1186/s13098-024-01424-7.
Imbalances in gut microbiota (GM) have been proposed as a potential contributing factor to diabetic complications; however, the causal relationship remains incompletely understood.
Summary statistics were obtained from genome-wide association studies (GWAS) of 196 gut microbial taxa, including 9 phyla, 16 classes, 20 orders, 32 families, and 119 genera. These data were then analyzed using mediation Mendelian randomization (MR) analyses to explore the potential mediating effect of diabetes complications risk factors on the relationship between gut microbiota and specific diabetic complications such as diabetic kidney disease (DKD), ketoacidosis, and diabetic retinopathy (DR).
In our Mendelian analysis, we observed negative associations between Bifidobacterial order and Actinomycete phylum with DKD in type 1 diabetes (T1D) as well as early DKD in T1D. Conversely, these taxa showed positive associations with ketoacidosis in type 2 diabetes (T2D). In reverse Mendelian analysis, we found that DR in both T1D and T2D as well as ketoacidosis in T2D affected the abundance of Eubacterium fissicaten genus and LachnospiraceaeUCG010 family within the gut microbiota.
Our findings provide compelling evidence for causal relationships between specific GM taxa and various diabetes complications. These insights contribute valuable knowledge for developing treatments targeting diabetes-related complications.
肠道微生物群（GM）失衡被认为是糖尿病并发症的一个潜在促成因素；然而，因果关系仍未完全明确。
从196种肠道微生物分类群的全基因组关联研究（GWAS）中获取汇总统计数据，这些分类群包括9个门、16个纲、20个目、32个科和119个属。然后使用中介孟德尔随机化（MR）分析对这些数据进行分析，以探讨糖尿病并发症风险因素对肠道微生物群与特定糖尿病并发症（如糖尿病肾病（DKD）、酮症酸中毒和糖尿病视网膜病变（DR））之间关系的潜在中介作用。
在我们的孟德尔分析中，我们观察到双歧杆菌目和放线菌门与1型糖尿病（T1D）中的DKD以及T1D中的早期DKD呈负相关。相反，这些分类群与2型糖尿病（T2D）中的酮症酸中毒呈正相关。在反向孟德尔分析中，我们发现T1D和T2D中的DR以及T2D中的酮症酸中毒会影响肠道微生物群中裂殖真杆菌属和毛螺菌科UCG010家族的丰度。
我们的研究结果为特定GM分类群与各种糖尿病并发症之间的因果关系提供了有力证据。这些见解为开发针对糖尿病相关并发症的治疗方法提供了有价值的知识。
