Li Hanjing, Li Candong
College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Front Microbiol. 2023 Aug 24;14:1184734. doi: 10.3389/fmicb.2023.1184734. eCollection 2023.
Studies showed that development of gut microbial dysbiosis has a close association with type 2 diabetes (T2D). It is not yet clear if there is a causal relationship between gut microbiota and T2D.
The data collected from the published genome-wide association studies (GWASs) on gut microbiota and T2D were analyzed. Two-sample Mendelian randomization (MR) analyses were performed to identify causal relationship between bacterial taxa and T2D. Significant bacterial taxa were further analyzed. To confirm the findings' robustness, we performed sensitivity, heterogeneity, and pleiotropy analyses. A reverse MR analysis was also performed to check for potential reverse causation.
By combining the findings of all the MR steps, we identified six causal bacterial taxa, namely, and . The risk of T2D might be positively associated with a high relative abundance of and but negatively associated with and The results of MR analyses revealed that there were causal relationships between the six different genera and T2D. And the reverse MR analysis did not reveal any evidence of a reverse causality.
This study implied that and might have anti-protective effect on T2D, whereas , and genera might have protective effect on T2D. Our study revealed that there was a causal relationship between specific gut microbiota genera and T2D.
研究表明肠道微生物群失调的发展与2型糖尿病（T2D）密切相关。肠道微生物群与T2D之间是否存在因果关系尚不清楚。
对已发表的关于肠道微生物群和T2D的全基因组关联研究（GWAS）收集的数据进行分析。进行两样本孟德尔随机化（MR）分析以确定细菌分类群与T2D之间的因果关系。对重要的细菌分类群进行进一步分析。为了确认研究结果的稳健性，我们进行了敏感性、异质性和多效性分析。还进行了反向MR分析以检查潜在的反向因果关系。
通过综合所有MR步骤的结果，我们确定了六个因果细菌分类群，即 和 。T2D的风险可能与 和 的高相对丰度呈正相关，但与 和 呈负相关。MR分析结果表明，这六个不同属与T2D之间存在因果关系。并且反向MR分析未发现任何反向因果关系的证据。
本研究表明 和 可能对T2D具有抗保护作用，而 、 和 属可能对T2D具有保护作用。我们的研究表明特定肠道微生物群属与T2D之间存在因果关系。
