Ko Albert Min-Shan, Wu Pei-Wen, Lin Wei-Ting, Lee Chien-Hung
Department and Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.
Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Oral Dis. 2025 May;31(5):1517-1530. doi: 10.1111/odi.15106. Epub 2024 Aug 20.
This study aimed to provide a comprehensive assessment of the measurement and prevalence of betel-quid (BQ) abuse, dependence, and BQ use disorder (BUD), as well as to evaluate the impact of BQ addiction on oral malignant diseases.
We used the PRISMA guidelines to perform a systematic review and meta-analysis. We searched for relevant publications up to April 2024 in PubMed, Web of Science, and Embase. The articles were evaluated for BQ addiction and its relationship with oral potentially malignant disorders (OPMD) and oral cancer.
The prevalence of BQ abuse, dependence, and BUD in South, Southeast, and East Asia varied between 0.8%-46.3%, 0.4%-43.5%, and 4.7%-39.2%, respectively. Among BQ chewers, the corresponding proportions of these disorders ranged from 40.5%-99.6%, 20.9%-99.6%, and 55.2%-99.3%. The pooled risks of OPMD associated with BQ abuse, dependence, and BUD were 16.3, 18.7, and 9.6-35.5, respectively. The risk of oral cancer for mild, moderate, and severe BUD was 8.5, 8.2, and 42.3, respectively.
BUD mediates the link between BQ use and an increased risk of oral malignant disorders. Addressing and treating BQ addiction is an important component of comprehensive OPMD and oral cancer preventive and intervention programs that go beyond simple cessation efforts.
本研究旨在全面评估槟榔咀嚼（BQ）滥用、依赖及槟榔使用障碍（BUD）的测量方法和患病率，并评估BQ成瘾对口腔恶性疾病的影响。
我们使用PRISMA指南进行系统评价和荟萃分析。在PubMed、科学网和Embase中检索截至2024年4月的相关出版物。对文章进行BQ成瘾及其与口腔潜在恶性疾病（OPMD）和口腔癌关系的评估。
南亚、东南亚和东亚地区BQ滥用、依赖及BUD的患病率分别在0.8%-46.3%、0.4%-43.5%和4.7%-39.2%之间。在BQ咀嚼者中，这些疾病的相应比例分别为40.5%-99.6%、20.9%-99.6%和55.2%-99.3%。与BQ滥用、依赖及BUD相关的OPMD合并风险分别为16.3%、18.7%和9.6%-35.5%。轻度、中度和重度BUD的口腔癌风险分别为8.5、8.2和42.3。
BUD介导了BQ使用与口腔恶性疾病风险增加之间的联系。解决和治疗BQ成瘾是全面的OPMD和口腔癌预防及干预项目的重要组成部分，而不仅仅是简单的戒烟努力。
