南亚、东南亚和东亚地区的槟榔成瘾性使用障碍、口腔潜在恶性疾病和口腔癌：一项系统评价和荟萃分析。

Betel-quid addictive use disorders and Oral potentially malignant disorders and Oral cancer in south, southeast, and East Asia: A systematic review and meta-analysis.

作者信息

Ko Albert Min-Shan, Wu Pei-Wen, Lin Wei-Ting, Lee Chien-Hung

机构信息

Department and Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.

Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.

出版信息

Oral Dis. 2025 May;31(5):1517-1530. doi: 10.1111/odi.15106. Epub 2024 Aug 20.

DOI:10.1111/odi.15106

PMID:39164987

Abstract

OBJECTIVE

This study aimed to provide a comprehensive assessment of the measurement and prevalence of betel-quid (BQ) abuse, dependence, and BQ use disorder (BUD), as well as to evaluate the impact of BQ addiction on oral malignant diseases.

METHODS

We used the PRISMA guidelines to perform a systematic review and meta-analysis. We searched for relevant publications up to April 2024 in PubMed, Web of Science, and Embase. The articles were evaluated for BQ addiction and its relationship with oral potentially malignant disorders (OPMD) and oral cancer.

RESULTS

The prevalence of BQ abuse, dependence, and BUD in South, Southeast, and East Asia varied between 0.8%-46.3%, 0.4%-43.5%, and 4.7%-39.2%, respectively. Among BQ chewers, the corresponding proportions of these disorders ranged from 40.5%-99.6%, 20.9%-99.6%, and 55.2%-99.3%. The pooled risks of OPMD associated with BQ abuse, dependence, and BUD were 16.3, 18.7, and 9.6-35.5, respectively. The risk of oral cancer for mild, moderate, and severe BUD was 8.5, 8.2, and 42.3, respectively.

CONCLUSIONS

BUD mediates the link between BQ use and an increased risk of oral malignant disorders. Addressing and treating BQ addiction is an important component of comprehensive OPMD and oral cancer preventive and intervention programs that go beyond simple cessation efforts.

摘要

目的

本研究旨在全面评估槟榔咀嚼（BQ）滥用、依赖及槟榔使用障碍（BUD）的测量方法和患病率，并评估BQ成瘾对口腔恶性疾病的影响。

方法

我们使用PRISMA指南进行系统评价和荟萃分析。在PubMed、科学网和Embase中检索截至2024年4月的相关出版物。对文章进行BQ成瘾及其与口腔潜在恶性疾病（OPMD）和口腔癌关系的评估。

结果

南亚、东南亚和东亚地区BQ滥用、依赖及BUD的患病率分别在0.8%-46.3%、0.4%-43.5%和4.7%-39.2%之间。在BQ咀嚼者中，这些疾病的相应比例分别为40.5%-99.6%、20.9%-99.6%和55.2%-99.3%。与BQ滥用、依赖及BUD相关的OPMD合并风险分别为16.3%、18.7%和9.6%-35.5%。轻度、中度和重度BUD的口腔癌风险分别为8.5、8.2和42.3。