美国成年人血清神经丝轻链与尿白蛋白排泄量的 J 型关系：NHANES 2013-2014 年。
J-shaped relationship of serum neurofilament light chain with urinary albumin excretion in US adults: NHANES 2013-2014.
机构信息
Tianjin Union Medical Center, Tianjin Medical University, Tianjin, China.
Department of Neurology, Tianjin Union Medical Center, Tianjin, China.
出版信息
Ren Fail. 2024 Dec;46(2):2391955. doi: 10.1080/0886022X.2024.2391955. Epub 2024 Aug 21.
INTRODUCTION
This study focuses on investigating the relationship between serum neurofilament light chain (sNfL) and urinary albumin-to-creatinine ratio (uACR) among American adults aged 25-75.
METHODS
An analysis was conducted on information gathered from 1741 individuals aged between 25 and 75 who participated in the National Health and Nutrition Examination Survey (NHANES) during the years 2013-2014. Generalized linear models were utilized, and restricted cubic spline (RCS) analysis was conducted to assess a non-linear relationship.
RESULTS
Upon adjusting for multiple variables, a non-linear inverse J-shaped relationship was observed between sNfL and uACR. Compared with individuals in quartile 1 (Q1) of sNfL (2.8-8.3), those with quartile 4 (Q4) (≥19.1) had an adjusted for uACR of 51.57.
CONCLUSIONS
The study found a J-shaped curve linking sNfL and uACR in American adults, with a turning point around log(sNfL) 2.928 pg/mL.
简介
本研究旨在探讨美国 25-75 岁成年人血清神经丝轻链（sNfL）与尿白蛋白/肌酐比值（uACR）之间的关系。
方法
对 2013-2014 年参加国家健康和营养检查调查（NHANES）的 1741 名年龄在 25-75 岁的个体进行了分析。采用广义线性模型，并进行受限立方样条（RCS）分析以评估非线性关系。
结果
在调整了多个变量后，sNfL 和 uACR 之间观察到非线性的倒 J 形关系。与 sNfL 四分位 1（Q1）（2.8-8.3）的个体相比，sNfL 四分位 4（Q4）（≥19.1）的个体调整后的 uACR 为 51.57。
结论
该研究发现美国成年人中 sNfL 和 uACR 之间存在 J 形曲线，转折点约为 log(sNfL) 2.928 pg/mL。
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