Tianjin Union Medical Center, Tianjin Medical University, Tianjin, China.
Department of Neurology, Tianjin Union Medical Center, Tianjin, China.
Ren Fail. 2024 Dec;46(2):2391955. doi: 10.1080/0886022X.2024.2391955. Epub 2024 Aug 21.
This study focuses on investigating the relationship between serum neurofilament light chain (sNfL) and urinary albumin-to-creatinine ratio (uACR) among American adults aged 25-75.
An analysis was conducted on information gathered from 1741 individuals aged between 25 and 75 who participated in the National Health and Nutrition Examination Survey (NHANES) during the years 2013-2014. Generalized linear models were utilized, and restricted cubic spline (RCS) analysis was conducted to assess a non-linear relationship.
Upon adjusting for multiple variables, a non-linear inverse J-shaped relationship was observed between sNfL and uACR. Compared with individuals in quartile 1 (Q1) of sNfL (2.8-8.3), those with quartile 4 (Q4) (≥19.1) had an adjusted for uACR of 51.57.
The study found a J-shaped curve linking sNfL and uACR in American adults, with a turning point around log(sNfL) 2.928 pg/mL.
本研究旨在探讨美国 25-75 岁成年人血清神经丝轻链（sNfL）与尿白蛋白/肌酐比值（uACR）之间的关系。
对 2013-2014 年参加国家健康和营养检查调查（NHANES）的 1741 名年龄在 25-75 岁的个体进行了分析。采用广义线性模型，并进行受限立方样条（RCS）分析以评估非线性关系。
在调整了多个变量后，sNfL 和 uACR 之间观察到非线性的倒 J 形关系。与 sNfL 四分位 1（Q1）（2.8-8.3）的个体相比，sNfL 四分位 4（Q4）（≥19.1）的个体调整后的 uACR 为 51.57。
该研究发现美国成年人中 sNfL 和 uACR 之间存在 J 形曲线，转折点约为 log(sNfL) 2.928 pg/mL。
