Lagacé-Thomassin Florence, Nateghi Ariana, Kechichian Elio, Veilleux Mylène
Department of Dermatology, University of Sherbrooke, Sherbrooke, QC, Canada.
SAGE Open Med Case Rep. 2024 Aug 19;12:2050313X241274916. doi: 10.1177/2050313X241274916. eCollection 2024.
Imiquimod is a well-known topical treatment for its efficacy against various skin conditions. While generally well-tolerated, adverse reactions like local skin irritation are common. However, severe systemic effects such as Stevens-Johnson syndrome (SJS) are rare, but possible. We present the case of an 82-year-old male who developed SJS following topical Imiquimod therapy for basal cell carcinoma. Despite minimal systemic absorption, serious reactions can occur, warranting caution. Prompt recognition and discontinuation of treatment are crucial for managing such rare but severe adverse events. This case underscores the importance of informed consent and vigilant monitoring for adverse reactions associated with Imiquimod therapy.
咪喹莫特是一种著名的局部治疗药物，对多种皮肤疾病都有疗效。虽然一般耐受性良好，但局部皮肤刺激等不良反应很常见。然而，严重的全身效应如史蒂文斯-约翰逊综合征（SJS）虽罕见但有可能发生。我们报告一例82岁男性患者，其在接受咪喹莫特局部治疗基底细胞癌后发生了SJS。尽管全身吸收极少，但仍可能发生严重反应，因此需要谨慎。及时识别并停止治疗对于处理此类罕见但严重的不良事件至关重要。该病例强调了知情同意以及对咪喹莫特治疗相关不良反应进行密切监测的重要性。
