木犀草素及其生物学和药理学活性的最新见解。 - Suppr

Recent insights into luteolin and its biological and pharmacological activities.

作者信息

Nadalin Priscilla, Kim Jae Kwang, Park Sang Un

机构信息

Department of Crop Science, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Korea.

Division of Life Sciences and Convergence Research Center for Insect Vectors, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Korea.

出版信息

EXCLI J. 2024 May 16;23:787-794. doi: 10.17179/excli2024-7168. eCollection 2024.

DOI:10.17179/excli2024-7168

PMID:39165588

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11333740/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a8/11333740/0d480cd5e2e1/EXCLI-23-787-t-001.jpg

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Recent insights into luteolin and its biological and pharmacological activities.木犀草素及其生物学和药理学活性的最新见解。

EXCLI J. 2024 May 16;23:787-794. doi: 10.17179/excli2024-7168. eCollection 2024.

Distribution and biological activities of the flavonoid luteolin.黄酮类化合物木犀草素的分布及生物活性

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Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3'-Disulfate.木樨草素及其 7,3'-二硫酸盐的药理学特性比较研究。

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A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis.芦丁防治 COVID-19/哮喘合并症的药理学机制探索的实用策略：系统药理学和生物信息学分析的结果。

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Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis.抗氧化酶活性参与木犀草素诱导人肺鳞癌CH27细胞凋亡。

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Occurrence of Luteolin in the Greek Flora, Isolation of Luteolin and Its Action for the Treatment of Periodontal Diseases.叶黄素在希腊植物群中的出现、叶黄素的分离及其在牙周病治疗中的作用。

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Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways.木樨草素通过 ERK1/2 和 PI3K/Akt 通路增强 PC12 细胞的胆碱能活性。

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Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis.木樨草素的抗炎作用与肠道微生物群的变化有关，并有助于防止单纯性脂肪变性向非酒精性脂肪性肝炎发展。

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The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells.黄酮类化合物木犀草素可减少亨廷顿蛋白突变的神经母细胞瘤细胞中突变型亨廷顿蛋白的聚集和细胞毒性。

Saudi Pharm J. 2023 Dec;31(12):101871. doi: 10.1016/j.jsps.2023.101871. Epub 2023 Nov 21.

Lonicera japonica Thunb extract ameliorates lipopolysaccharide-induced acute lung injury associated with luteolin-mediated suppression of NF-κB signaling pathway.忍冬提取物通过木犀草素介导的核因子κB信号通路抑制改善脂多糖诱导的急性肺损伤。

J Inflamm (Lond). 2023 Dec 19;20(1):44. doi: 10.1186/s12950-023-00372-9.

Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions.木犀草素通过阻断 ROS/PI3K/AKT 通路抑制间皮-间充质转化，减少腹腔粘连。

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Luteolin inhibits the JAK/STAT pathway to alleviate auditory cell apoptosis of acquired sensorineural hearing loss based on network pharmacology, molecular docking, molecular dynamics simulation, and experiments in vitro.基于网络药理学、分子对接、分子动力学模拟以及体外实验研究，木犀草素通过抑制 JAK/STAT 通路缓解获得性感音神经性听力损失的听觉细胞凋亡。

Toxicol Appl Pharmacol. 2024 Jan;482:116790. doi: 10.1016/j.taap.2023.116790. Epub 2023 Dec 15.

Luteolin prevents TNF-α-induced NF-κB activation and ROS production in cultured human placental explants and endothelial cells.木樨草素可预防 TNF-α 诱导的人胎盘组织培养物和内皮细胞中 NF-κB 的激活和 ROS 的产生。

Placenta. 2024 Jan;145:65-71. doi: 10.1016/j.placenta.2023.12.004. Epub 2023 Dec 8.

Molecules. 2023 Nov 22;28(23):7720. doi: 10.3390/molecules28237720.

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway.木犀草素通过激活Nrf2信号通路减轻避水应激大鼠的氧化应激和结肠过度运动

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Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis.木犀草素可抑制糖蛋白VI介导的血小板活化、氧化应激和血栓形成。

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Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury.运用网络药理学与实验验证相结合的方法来探究木樨草素缓解伏马菌素 B1 诱导的肠道炎症性损伤的作用机制。

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Effects and Mechanism of Luteolin on Proliferation and Apoptosis of Glioma.木樨草素对神经胶质瘤细胞增殖和凋亡的影响及机制。

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Recent insights into luteolin and its biological and pharmacological activities.

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